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Titolo:
Clinical features of familial gout and effects of probable genetic association between gout and its related disorders
Autore:
Chen, SY; Chen, CL; Shen, ML; Kamatani, NY;
Indirizzi:
Taipei Municipal Chron Dis Hosp, Clin Rheumatol, Dept Internal Med, Taipei, Taiwan Taipei Municipal Chron Dis Hosp Taipei Taiwan ernal Med, Taipei, Taiwan Taipei Municipal Hosp, Gout Res Grp, Taipei, Taiwan Taipei Municipal HospTaipei Taiwan Hosp, Gout Res Grp, Taipei, Taiwan Taipei Municipal Ho Ping Hosp, Clin Gout, Taipei, Taiwan Taipei Municipal Ho Ping Hosp Taipei Taiwan , Clin Gout, Taipei, Taiwan Natl Taiwan Univ, Dept Agron, Div Biometry, Taipei, Taiwan Natl Taiwan Univ Taipei Taiwan Dept Agron, Div Biometry, Taipei, Taiwan Tokyo Womens Med Coll, Inst Rheumatol, Tokyo 162, Japan Tokyo Womens Med Coll Tokyo Japan 162 , Inst Rheumatol, Tokyo 162, Japan
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 10, volume: 50, anno: 2001,
pagine: 1203 - 1207
SICI:
0026-0495(200110)50:10<1203:CFOFGA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERURICEMIC NEPHROPATHY; JAPANESE FAMILY; URIC-ACID; PLASMA; HYPERTRIGLYCERIDEMIA; RESISTANCE; CLEARANCE; ARTHRITIS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Chen, SY Taipei Municipal Chron Dis Hosp, Clin Rheumatol, Dept Internal Med, 530 Lin Sen N Rd, Taipei, Taiwan Taipei Municipal Chron Dis Hosp 530 LinSen N Rd Taipei Taiwan
Citazione:
S.Y. Chen et al., "Clinical features of familial gout and effects of probable genetic association between gout and its related disorders", METABOLISM, 50(10), 2001, pp. 1203-1207

Abstract

We examined whether the age at onset, gender, arthritic manifestations, and tophus formation in familial gout are different from those in nonfamilialgout, and we also examined the contributory effect of genetic association to the concurrence of hypertriglyceridemia, hypercholesterolemia, type 2 diabetes mellitus (DM), hypertension, obesity, and renal insufficiency with gout in Taiwan. A total of 21,373 gout patients' data from Ho-Ping Gout database were analyzed in this study retrospectively. The clinical and laboratory data were compared between familial and nonfamilial gout. Mean age at onset of gout in familial subjects was significantly 7.5 years lower than that of nonfamilial subjects (40.9 +/- 13.4 v 48.4 +/- 14.2 years, P = .0001),while gender, arthritic severity, and tophus formation were not significantly different between these 2 groups. Familial gout had lower serum triglyceride (TG), total cholesterol (TC), and percentage of hypertension than nonfamilial gout (182.4 +/- 125.3 v 195.9 +/- 135.8 mg/dL, P = .0001; 207.5 +/- 42.5 v 210.4 +/- 48.8 mg/dL, P = .0003; and 19.57% v 22.56%, P < .0001, respectively). Their serum creatinine, body mass index (BMI), and percentageof type 2 DM were not significantly different. Our results demonstrate that familial gout is associated with precocious onset. Furthermore, the contributory effect of genetic association to the concurrence of hyperlipidemia and hypertension with gout is less than that of environmental factors, while the effect of genetic association to the concurrence of obesity, type 2 DM, and renal insufficiency with gout is equivalent to that of environmentalfactors. Copyright (C) 2001 by W.B. Saunders Company.

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Documento generato il 22/01/20 alle ore 12:26:45