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Titolo:
Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States
Autore:
Kalhan, R; Puthawala, K; Agarwal, S; Amini, SB; Kalhan, SC;
Indirizzi:
Case Western Reserve Univ, Metrohlth Med Ctr, Sch Med, Robert Schwartz MD Ctr Metab & Nutr, Cleveland, OH 44109 USA Case Western Reserve Univ Cleveland OH USA 44109 Cleveland, OH 44109 USA Case Western Reserve Univ, Metrohlth Med Ctr, Sch Med, Gen Clin Res Ctr, Cleveland, OH 44109 USA Case Western Reserve Univ Cleveland OH USA 44109 Cleveland, OH 44109 USA
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 10, volume: 50, anno: 2001,
pagine: 1197 - 1202
SICI:
0026-0495(200110)50:10<1197:ALPLIA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; TOTAL HOMOCYSTEINE; RISK FACTOR; INDIAN MEN; RESISTANCE; HYPERINSULINEMIA; LIPOPROTEIN(A); OBESITY; FAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kalhan, SC Case Western Reserve Univ, Metrohlth Med Ctr, Sch Med, Robert Schwartz MD Ctr Metab & Nutr, BG-774,2500 MetroHlth Dr, Cleveland, OH 44109 USA Case Western Reserve Univ BG-774,2500 MetroHlth Dr Cleveland OH USA 44109
Citazione:
R. Kalhan et al., "Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States", METABOLISM, 50(10), 2001, pp. 1197-1202

Abstract

South Asians who immigrate to the United States have a propensity toward insulin resistance, central obesity, and elevated total cholesterol:high-density lipoprotein (HDL) ratio. To evaluate whether these alterations are apparent at a younger age, we studied 32 offspring of South Asian immigrants and compared them with 29 of European descent between 18 to 30 years of age. American-born South Asian males had significantly higher total cholesterol, low-density lipoprotein (TC:LDL) ratios, triglycerides, and fasting insulin levels (13.9 +/- 7.1 and 10.0 +/- 5.5 muU/mL, P < .01) than their European counterparts. The South Asian females only had increased plasma insulin levels (15.3 +/- 8.8 and 10.0 +/- 5.1 muU/mL, P = .05). The entire South Asian group had higher truncal skinfold thickness (40.1 +/- 18.1 and 30.3 +/-12.6 mm, P = < .05) and lower insulin-like growth factor binding protein (IGFBP)-1 levels (46.8 +/- 33.4 and 56.0 +/- 33.4 mug/L, P = .05). Plasma leptin levels were also significantly higher in both males (4.3 +/- 2.5 v 2.8+/- 1.3 ng/mL, P = .0001) and females (20.5 +/- 10.3 v 10.3 +/- 6.3 ng/mL,P = .002) South Asian subjects. A significant correlation between plasma leptin and insulin, triglycerides, TC, and body mass index (BMI) was seen inthe South Asian males. South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear. Copyright (C) 2001 by WB. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 12:50:21