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Titolo:
A simplified method to quantitate atherosclerosis in the rabbit aorta
Autore:
Blumel, JE; Castelo-Branco, C; Sanjuan, A; Gonzalez, P; Moyano, C; Iturriaga, TM; Gonzalez, R; Romero, S; Cano, A;
Indirizzi:
Hosp Clin Barcelona, Dept Obstet & Gynecol, Barcelona 08036, Spain Hosp Clin Barcelona Barcelona Spain 08036 ynecol, Barcelona 08036, Spain Barros Luco Tradeau Hosp, Climacter Unit, Santiago, Chile Barros Luco Tradeau Hosp Santiago Chile Climacter Unit, Santiago, Chile Inst Publ Hlth, Santiago, Chile Inst Publ Hlth Santiago ChileInst Publ Hlth, Santiago, Chile USACH Med Sch, Santiago, Chile USACH Med Sch Santiago ChileUSACH Med Sch, Santiago, Chile Univ Valencia, Valencia, Spain Univ Valencia Valencia SpainUniv Valencia, Valencia, Spain
Titolo Testata:
MATURITAS
fascicolo: 3, volume: 39, anno: 2001,
pagine: 265 - 271
SICI:
0378-5122(20010928)39:3<265:ASMTQA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE REPLACEMENT THERAPY; CORONARY HEART-DISEASE; MEDROXYPROGESTERONE ACETATE; PLASMA-LIPIDS; LIPOPROTEINS; ESTROGEN; WOMEN; OOPHORECTOMY; MENOPAUSE; APOLIPOPROTEINS;
Keywords:
aorta; cholesterol; rabbits; hypercholesterolemia; computing images;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Castelo-Branco, C Hosp Clin Barcelona, Dept Obstet & Gynecol, Villarroel 170, Barcelona 08036, Spain Hosp Clin Barcelona Villarroel 170 Barcelona Spain 08036
Citazione:
J.E. Blumel et al., "A simplified method to quantitate atherosclerosis in the rabbit aorta", MATURITAS, 39(3), 2001, pp. 265-271

Abstract

A simple method to quantitatively evaluate atherosclerosis in the rabbit aorta by measuring macroscopic lesion areas (%) was attempted in the presentstudy. Ten female New Zealand white rabbits were fed on a cholesterol-richdiet (5/1000 g of food) during 4 months. Five of them were oophorectomizedat the beginning and all were sacrificed at the end. Total levels of cholesterol increased from 50.7 +/- 14.7 mg/dl to 782.8 +/- 296.0. No significant differences were observed between oophorectomized and intact rabbits. At 4 months, the cholesterol-rich diet caused in both, intact and oophorectomized rabbits, atherosclerotic lesions affecting 17 and 46% of the aortic surface, respectively. This method may be more practical, easy and useful for quantitative evaluation of aortic atherosclerosis in a large number of rabbits, than histological observations of serial sections of rabbit's aortas. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:00:03