Catalogo Articoli (Spogli Riviste)

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Titolo:
Selection criteria for liver transplantation in early-stage hepatocellularcarcinoma with cirrhosis: Results of a multicenter study
Autore:
Figueras, J; Ibanez, L; Ramos, E; Jaurrieta, E; Ortiz-de-Urbina, J; Pardo, F; Mir, J; Loinaz, C; Herrera, L; Lopez-Cillero, P; Santoyo, J;
Indirizzi:
Ciudad Sanitaria & Univ Bellvitge, Barcelona, Spain Ciudad Sanitaria & Univ Bellvitge Barcelona Spain tge, Barcelona, Spain Hosp Cruces, Bilbao, Spain Hosp Cruces Bilbao SpainHosp Cruces, Bilbao, Spain Clin Univ Navarra, Pamplona, Spain Clin Univ Navarra Pamplona SpainClin Univ Navarra, Pamplona, Spain Hosp La Fe, E-46009 Valencia, Spain Hosp La Fe Valencia Spain E-46009Hosp La Fe, E-46009 Valencia, Spain Hosp 12 Octubre, E-28041 Madrid, Spain Hosp 12 Octubre Madrid Spain E-28041 p 12 Octubre, E-28041 Madrid, Spain Hosp Marques Valdecilla, Santander, Spain Hosp Marques Valdecilla Santander Spain es Valdecilla, Santander, Spain Hosp Reina Sofia, Cordoba, Spain Hosp Reina Sofia Cordoba SpainHosp Reina Sofia, Cordoba, Spain Hosp Carlos Haya, Malaga, Spain Hosp Carlos Haya Malaga SpainHosp Carlos Haya, Malaga, Spain
Titolo Testata:
LIVER TRANSPLANTATION
fascicolo: 10, volume: 7, anno: 2001,
pagine: 877 - 883
SICI:
1527-6465(200110)7:10<877:SCFLTI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESECTION; CLASSIFICATION; SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Figueras, J Bellvitge Hosp, Liver Transplant Unit, C Feixa Llarga S-N, E-08907 Barcelona, Spain Bellvitge Hosp C Feixa Llarga S-N Barcelona Spain E-08907 ain
Citazione:
J. Figueras et al., "Selection criteria for liver transplantation in early-stage hepatocellularcarcinoma with cirrhosis: Results of a multicenter study", LIVER TRANS, 7(10), 2001, pp. 877-883

Abstract

Orthotopic liver transplantation (OLT) offers the only chance to eliminateboth tumor and liver disease in patients with hepatocellular carcinoma (HCC) and cirrhosis. However, tumor progression while on the waiting list and recurrence after OLT are frequent. We undertook a large multicenter study to assess survival and related factors of recurrence after OLT. This retrospective study analyses data from 307 consecutive patients with HCC, and cirrhosis treated with OLT between 1990 and 1997 in eight centers in Spain. OLTwas indicated only for small (< 5 cm) localized tumors. Five-year rates after OLT were 63% for survival, 58% for disease-free survival, and 21 % for recurrence. Tumor diameter larger than 5 cm was associated with other tumorcharacteristics that were significant indicators of poor outcome (absence of capsule, three or more nodules, bilobularity, satellite nodules, and vascular invasion). However, in multivariate analysis, alpha fetoprotein (AFP)levels greater than 300 ng/mL, (P = .04; P = .02) and macroscopic vascularinvasion (P = .01; P = .0001) were the only factors independently associated with mortality and recurrence, respectively. OLT is indicated in patients with small HCCs who have low AFP levels and no macroscopic vascular invasion or extrahepatic disease. By increasing our ability for preoperative tumor imaging, we will achieve better selection of patients with HCC before OLT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/02/20 alle ore 22:09:52