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Titolo:
Impaired conditioned taste aversion learning in spinophilin knockout mice
Autore:
Stafstrom-Davis, CA; Ouimet, CC; Feng, J; Allen, PB; Greengard, P; Houpt, TA;
Indirizzi:
Florida State Univ, Neurosci Program, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 am, Tallahassee, FL 32306 USA Rockefeller Univ, Mol & Cellular Neurosci Lab, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 urosci Lab, New York, NY 10021 USA
Titolo Testata:
LEARNING & MEMORY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 272 - 278
SICI:
1072-0502(200109/10)8:5<272:ICTALI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENDRITIC SPINE DENSITY; DEPENDENT PROTEIN-KINASE; RAT HIPPOCAMPAL-NEURONS; LONG-TERM DEPRESSION; C-FOS; POSTSYNAPTIC DENSITY; BINDING-PROTEIN; PYRAMIDAL CELLS; IN-VIVO; PHOSPHATASE-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Houpt, TA Florida State Univ, Neurosci Program, Tallahassee, FL 32306 USA Florida State Univ Tallahassee FL USA 32306 assee, FL 32306 USA
Citazione:
C.A. Stafstrom-Davis et al., "Impaired conditioned taste aversion learning in spinophilin knockout mice", LEARN MEM, 8(5), 2001, pp. 272-278

Abstract

Plasticity in dendritic spines may underlie learning and memory. Spinophilin, a protein enriched in dendritic spines, has the properties of a scaffolding protein and is believed to regulate actin cytoskeletal dynamics affecting dendritic spine morphology. It also binds protein phosphatase-1 (PP-1),an enzyme that regulates dendritic spine physiology. In this study, we tested the role of spinophilin in conditioned taste aversion learning (CTA) using transgenic spinophilin knockout mice. CTA is a form of associative learning in which an animal rejects a food that has been paired previously witha toxic effect (e.g., a sucrose solution paired with a malaise-inducing injection of lithium chloride). Acquisition and extinction of CTA was tested in spinophilin knockout and wild-type mice using taste solutions (sucrose or sodium chloride) or flavors (Kool-Aid) paired with moderate or high dosesof LiCl (0-15 M, 20 or 40 mL/kg). When sucrose or NaCl solutions were paired with a moderate dose of LiCl, spinophilin knockout mice were unable to learn a CTA. At the higher dose, knockout mice acquired a CTA but extinguished more rapidly than wild-type mice. A more salient flavor stimulus (taste plus odor) revealed similar CTA learning at both doses of LiCl in both knockouts and wild types. Sensory processing in the knockouts appeared normal because knockout mice and wild-type mice expressed identical unconditioned taste preferences in two-bottle tests, and identical lying-on-belly responses to acute LiCl. We conclude that spinophilin is a candidate molecule required for normal CTA learning.

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Documento generato il 18/01/20 alle ore 07:29:08