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Titolo:
Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region
Autore:
Roberto, M; Scuri, R; Brunelli, M;
Indirizzi:
Univ Pisa, Dept Physiol & Biochem G Moruzzi, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 ol & Biochem G Moruzzi, I-56127 Pisa, Italy
Titolo Testata:
LEARNING & MEMORY
fascicolo: 5, volume: 8, anno: 2001,
pagine: 265 - 271
SICI:
1072-0502(200109/10)8:5<265:DEOPOS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; VASOACTIVE-INTESTINAL-PEPTIDE; LONG-TERM POTENTIATION; SYMPATHETIC PREGANGLIONIC NEURONS; CORTICAL-NEURONS; INDEPENDENT MECHANISM; MUSCARINIC RECEPTORS; BINDING-SITES; ACETYLCHOLINE; GLUTAMATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Roberto, M Univ Pisa, Dept Physiol & Biochem G Moruzzi, San Zeno 31, I-56127 Pisa, Italy Univ Pisa San Zeno 31 Pisa Italy I-56127 , I-56127 Pisa, Italy
Citazione:
M. Roberto et al., "Differential effects of PACAP-38 on synaptic responses in rat hippocampal CA1 region", LEARN MEM, 8(5), 2001, pp. 265-271

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP-38) is a member of the vasointestinal polypeptide (VIP)/secretin/glucagon family of neuropeptides for which neuroregulatory functions have been postulated. PACAP-38 receptors are expressed in different brain regions, including hippocampus. In this study, we examined the dose-dependent effects of PACAP-38 on the excitatory postsynaptic field potential (fEPSP) evoked at the Schaffer collateral-CA1 synapse in rat hippocampal slices. Bath application of low dose (0.05 nM) of PACAP-38 induced long-lasting facilitation of the fEPSP. This enhancement was blocked by the cholinergic receptor antagonist atropine and partially by the NMDA receptor antagonist 2-amino-5-phosphonovalerate (APV) and therefore, shares a common mechanism with LTP. In contrast, a high dose (I muM) of PACAP-38 induced a persistent depression of the fEPSP that was not blocked by antagonists of cholinergic receptors (i.e., atropine and mecamylamine), adenosine receptors (i.e., DCPCX), or glutamatergic NMDA receptors (APV). Intermediate doses (0.1-0.5 muM) of PACAP-38 produced an initial decrease of the fEPSP followed by an enhancement. This decrease was not blocked by atropine whereas the facilitation was. These results show that PACAP-38 modulates CAI synaptic transmission in a dose-dependent manner and that the peptide interacts with cholinergic and glutamatergic systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:15:14