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Titolo:
MR imaging-histopathologic correlation of radiofrequency thermal ablation lesion in a rabbit liver model: Observation during acute and chronic stages
Autore:
Lee, JD; Lee, JM; Kim, SW; Kim, CS; Mun, WS;
Indirizzi:
Chonbuk Natl Univ, Med Sch, Dept Surg Pathol, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea t Surg Pathol, Chonju, South Korea Kwangju Wonkwang Hosp, Dept Diagnost Radiol, Kwangju, South Korea Kwangju Wonkwang Hosp Kwangju South Korea Radiol, Kwangju, South Korea Chonbuk Natl Univ, Med Sch, Dept Diagnost Radiol, Chonju, South Korea Chonbuk Natl Univ Chonju South Korea agnost Radiol, Chonju, South Korea
Titolo Testata:
KOREAN JOURNAL OF RADIOLOGY
fascicolo: 3, volume: 2, anno: 2001,
pagine: 151 - 158
SICI:
1229-6929(200107/09)2:3<151:MICORT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL HEPATOCELLULAR-CARCINOMA; TISSUE ABLATION; FOLLOW-UP; THERAPY; TUMORS; METASTASES; CANCER; LASER; CT;
Keywords:
liver, MR; liver, interventional procedure interventional procedures, experimental;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JM Chonbuk Natl Univ Hosp, Dept Diagnost Radiol, 634-18 Keumam Dong, Chonju 561712, Chonbuk, South Korea Chonbuk Natl Univ Hosp 634-18 Keumam Dong Chonju Chonbuk South Korea 561712
Citazione:
J.D. Lee et al., "MR imaging-histopathologic correlation of radiofrequency thermal ablation lesion in a rabbit liver model: Observation during acute and chronic stages", KOREAN J RA, 2(3), 2001, pp. 151-158

Abstract

Objective: To determine the ability of MR imaging to detect the pathological changes occurring in radiofrequency (RF) thermal lesions and to assess its accuracy in revealing the extent of tissue necrosis. Materials and Methods: Using an RF electrode, thermal lesions were createdin the livers of 18 rabbits. The procedure involved three phases. In the acute phase, six animals were killed the day after performing thermal ablation with RF energy, and two on day 3. In the subacute and chronic phases, eight rabbits underwent percutaneous hepatic RF ablation. After performing MRimaging, two animals were sacrificed at 1, 2, 4, and 7 weeks after the procedure, and MR-pathologic correlation was performed. Results: In the acute phase, the thermal ablation lesions appeared at gross examination as well-circumscribed, necrotic areas, representing early change in the coagulative necrosis seen at microscopic examination. They were hypointense on T2-weighted images, and hyperintense on T1-weighted images. Gadolinium-enhanced MR imaging showed that a thin hyperemic rim surrounded the central coagulative necrosis. In the subacute phase, ablated lesions also showed extensive coagulative necrosis and marked inflammation at microscopic examination. Beyond two weeks, the lesions showed gradual resorption of the necrotic area, with a peripheral fibrovascular rim. The size of lesions measured by MR imaging correlated well with the findings at gross pathologic examination. Conclusion: MR imaging effectively demonstrates the histopathological tissue change occurring after thermal ablation, and accurately determines the extent of the target area.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 23:15:43