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Titolo:
Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status
Autore:
Baek, BS; Kim, JW; Lee, JH; Kwon, HJ; Kim, ND; Kang, HS; Yoo, MA; Yu, BP; Chung, HY;
Indirizzi:
Pusan Natl Univ, Coll Pharm, Dept Pharm, Gumjung Ku, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 g Ku, Pusan 609735, South Korea Pusan Natl Univ, Res Inst Genet Engn, Pusan 609735, South Korea Pusan NatlUniv Pusan South Korea 609735 Engn, Pusan 609735, South Korea Univ Texas, Hlth Sci Ctr, San Antonio, TX USA Univ Texas San Antonio TX USA v Texas, Hlth Sci Ctr, San Antonio, TX USA
Titolo Testata:
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
fascicolo: 10, volume: 56, anno: 2001,
pagine: B426 - B431
SICI:
1079-5006(200110)56:10<B426:AIOBCA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; ALZHEIMERS-DISEASE; COMPLEMENTARY-DNA; NITRIC-OXIDE; EXPRESSION; RESTRICTION; CYTOKINES; CLONING; CELLS; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, HY Pusan Natl Univ, Coll Pharm, Dept Pharm, Gumjung Ku, Pusan 609735, South Korea Pusan Natl Univ Pusan South Korea 609735 n 609735, South Korea
Citazione:
B.S. Baek et al., "Age-related increase of brain cyclooxygenase activity and dietary modulation of oxidative status", J GERONT A, 56(10), 2001, pp. B426-B431

Abstract

Several studies have demonstrated that inhibitors of cyclooxygenase (COX) attenuate various neuronal injuries and age-dependent demented conditions. From these findings, we proposed to test the effect of age on COX activity and its. possible suppression by the antiaging action of dietary restriction in the rat brain. The status of reactive oxygen species (ROS) was also assessed to correlate with COX activity to delineate the underlying mechanismof the altered COX activity during aging. These results showed that COX activity significantly increased in 24-month-old rats compared with 6-month-old rats in an ad libitum group. Interestingly, mRNA and protein levels of COX-2 showed little corresponding age-related change. The formation of ROS was found to increase gradually with age in ad libitum fed rats. However, dietary restriction suppressed the increase at the age of 24 months. To substantiate the relationship between ROS and COX activity when the rats were 24months of age, we conducted in vitro experiments with a C6 glioma cell line. Together, it is concluded that increased COX activity with age is due tothe activation of COX catalytic reaction by ROS without increased gene expression of COX-2 and that it is related to the increased pro-oxidant statusin aged rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 10:12:50