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Titolo:
Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology
Autore:
Watkins, BA; Li, Y; Seifert, MF;
Indirizzi:
Purdue Univ, Dept Food Sci, Lipid Chem & Mol Biol Lab, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 Biol Lab, W Lafayette, IN 47907 USA Indiana Univ, Sch Med, Dept Anat & Cell Biol, Indianapolis, IN USA IndianaUniv Indianapolis IN USA Anat & Cell Biol, Indianapolis, IN USA
Titolo Testata:
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
fascicolo: 5, volume: 20, anno: 2001, supplemento:, S
pagine: 410S - 416S
SICI:
0731-5724(200110)20:5<410S:NFAABA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
OSTEOCLAST DIFFERENTIATION FACTOR; BONE MORPHOGENETIC PROTEIN-2; PROSTAGLANDIN-MEDIATED MECHANISM; COA REDUCTASE INHIBITORS; MESSENGER-RNA LEVELS; RHEUMATOID-ARTHRITIS; OSTEOBLAST DIFFERENTIATION; PARATHYROID-HORMONE; STROMAL CELLS; IN-VITRO;
Keywords:
bone; cyclooxygenase; polyunsaturated fatty acids; eicosapentaenoic acid; osteoprotegerin; Cbfa1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Watkins, BA Purdue Univ, Dept Food Sci, Lipid Chem & Mol Biol Lab, Smith Hall, W Lafayette, IN 47907 USA Purdue Univ Smith Hall W Lafayette IN USA 47907 , IN 47907 USA
Citazione:
B.A. Watkins et al., "Nutraceutical fatty acids as biochemical and molecular modulators of skeletal biology", J AM COL N, 20(5), 2001, pp. 410S-416S

Abstract

Several systemic hormones and localized growth factors coordinate events of bone formation and resorption to support bone growth in the young and maintain bone mineral content in the adult. Some of the more important factorsproduced in the bone microenvironment that impact skeletal biology includeprostaglandins, cytokines, and insulin-like growth factors. Dietary fat sources that exert potent biological effects on the skeletal tissues belong to the omega-6 and omega-3 families of essential fatty acids. Specific long-chain polyunsaturated fatty acids (PUFA) belonging to these families are substrates for prostanoids that influence the differentiation and activity ofcells in bone and cartilage tissues. These PUFA appear to alter prostanoidformation, cell-to-cell signaling processes, and impact transcription factors in vivo. Hence, these biologically active PUFA can be called nutraceutical fatty acids. This review highlights the role of nutraceutical fatty acids on bone metabolism and joint disease. The recent discovery of transcription factors controlling osteoblast function, and soluble proteins directingosteoclastogenesis and osteoblastogenesis offer new research opportunitiesfor studying nutraceutical fatty acids in skeletal biology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:41:18