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Titolo:
Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells
Autore:
Kalme, T; Loukovaara, M; Koistinen, H; Koistinen, R; Seppala, M; Leinonen, P;
Indirizzi:
Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ol, FIN-00029 Helsinki, Finland
Titolo Testata:
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
fascicolo: 2, volume: 78, anno: 2001,
pagine: 131 - 135
SICI:
0960-0760(200108)78:2<131:FRIGFB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; IGF-I; DEXAMETHASONE TREATMENT; NONPARENCHYMAL CELLS; HORMONE GH; SERUM; RADIOIMMUNOASSAY; IGFBP-3; PLASMA; LIVER;
Keywords:
insulin-like growth factor; growth hormone; human serum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kalme, T Univ Helsinki, Cent Hosp, Dept Obstet & Gynecol, Haartmaninkatu 2, FIN-00029 Helsinki, Finland Univ Helsinki Haartmaninkatu 2 Helsinki Finland FIN-00029 inland
Citazione:
T. Kalme et al., "Factors regulating insulin-like growth factor binding protein-3 secretion from human hepatoma (HepG2) cells", J STEROID B, 78(2), 2001, pp. 131-135

Abstract

Insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) is a growth hormone (GH) dependent carrier of the IGFs in human serum. Apart from GH regulation the hormonal control of IGFBP-3 production is not well established and although the liver is considered to be the main source of circulating IGFBP-3, there are no in vitro studies of the effect of both insulin and IGFs on the IGFBP-3 produced in human hepatoma cells. The effect of sex hormones as well as cortisol has not been studied, To elucidate this we performedcell culture studies on HepG2 cells in the presence of various effectors. Insulin, IGF-I and IGF-II brought about a 1.5-2-fold enhancement of IGFBP-3release at 7.5-30 nM concentrations. In contrast, cortisol decreased IGFBP-3 secretion by 30-40%, whereas estradiol, tamoxifen and testosterone had no effect at physiological concentrations. We conclude that, in addition to GH, also insulin, IGF-I and IGF-II and glucocorticoids can modulate IGFBP-3secretion by human hepatoma cells. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:22:58