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Titolo:
Prognostic factors and secondary malignancies in childhood medulloblastoma
Autore:
Stavrou, T; Bromley, CM; Nicholson, HS; Byrne, J; Packer, RJ; Goldstein, AM; Reaman, GH;
Indirizzi:
Childrens Natl Med Ctr, Dept Hematol Oncol, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA Childrens Natl Med Ctr, Dept Neurol, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 , Washington, DC 20010 USA NCI, Genet Epidemiol Branch, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Genet Epidemiol Branch, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
fascicolo: 7, volume: 23, anno: 2001,
pagine: 431 - 436
SICI:
1077-4114(200110)23:7<431:PFASMI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL CARCINOMA SYNDROME; RADIATION-INDUCED MENINGIOMA; LONG-TERM SURVIVAL; BRAIN-TUMORS; RECURRENT MEDULLOBLASTOMA; CRANIOSPINAL IRRADIATION; YOUNG-CHILDREN; COLLINS LAW; CHEMOTHERAPY; VINCRISTINE;
Keywords:
medulloblastoma; prognostic factors; nevoid basal cell carcinoma syndrome; secondary malignancies;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Stavrou, T Childrens Natl Med Ctr, Dept Hematol Oncol, Washington, DC 20010 USA Childrens Natl Med Ctr Washington DC USA 20010 n, DC 20010 USA
Citazione:
T. Stavrou et al., "Prognostic factors and secondary malignancies in childhood medulloblastoma", J PED H ONC, 23(7), 2001, pp. 431-436

Abstract

Purpose: Little is known of the outcome of long-term survivors of childhood medulloblastoma, one of the most common pediatric malignancies. To determine the potential for secondary malignancies, a retrospective outcome evaluation in 88 consecutive cases of childhood medulloblastoma was performed. Patients and Methods: The records of all patients with childhood medulloblastoma diagnosed at Children's National Medical Center in Washington, DC from 1969 through 1997 were reviewed. Results: The median follow-up time was 92 months (range 6-257 months), Overall survival was 59% at 5 years and 52% at 10 years. Univariate analysis showed that age at diagnosis, extent of surgical resection, presence of metastatic disease (M stage), ventriculoperitoneal shunt placement within 30 days from diagnosis, posterior fossa radiation therapy dose, and adjuvant chemotherapy significantly affected survival. Although based on small numbers,the risk of second neoplasms was significantly increased in this cohort. Multiple basal cell carcinomas developed in the areas of radiation therapy in two patients;, these patients also had nevoid basal cell carcinoma syndrome (NBCCS) diagnosed. One other patient died of glioblastoma multiforme 8 years after treatment of medulloblastoma. A meningioma developed in another patient 10 years after radiation therapy. Conclusion: As survival of medulloblastoma patients improves, increased surveillance regarding secondary malignancies is required, especially becauseradiation-induced tumors may occur many years after treatment. These two cases of NBCCS also illustrate the importance of considering the concomitantdiagnosis of NBCCS in young patients with medulloblastoma. In those patients, alternative therapy should be considered to minimize radiation therapy-related sequelae.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:13:22