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Titolo:
Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia
Autore:
Oeffinger, KC; Buchanan, GR; Eshelman, DA; Denke, MA; Andrews, TC; Germak, JA; Tomlinson, GE; Snell, LE; Foster, BM;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Family Practice & Community Med, After Canc Experience Young Adult Program, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Young Adult Program, Dallas, TX 75390 USA Univ Texas, SW Med Ctr, Dept Pediat, Dallas, TX USA Univ Texas Dallas TX USA Texas, SW Med Ctr, Dept Pediat, Dallas, TX USA Univ Texas, SW Med Ctr, Ctr Canc & Blood Disorders, Dallas, TX USA Univ Texas Dallas TX USA Ctr, Ctr Canc & Blood Disorders, Dallas, TX USA Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Texas Dallas TX USA , SW Med Ctr, Dept Internal Med, Dallas, TX USA Univ Texas, SW Med Ctr Acad Comp Serv, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 d Ctr Acad Comp Serv, Dallas, TX 75235 USA Childrens Med Ctr Dallas, After Canc Experience Program, Dallas, TX USA Childrens Med Ctr Dallas Dallas TX USA xperience Program, Dallas, TX USA Ohio State Univ, Dept Pediat, Columbus, OH USA Ohio State Univ Columbus OH USA tate Univ, Dept Pediat, Columbus, OH USA
Titolo Testata:
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
fascicolo: 7, volume: 23, anno: 2001,
pagine: 424 - 430
SICI:
1077-4114(200110)23:7<424:CRFIYA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE DEFICIENCY; CORONARY HEART-DISEASE; BODY-MASS INDEX; CRANIAL IRRADIATION; PHYSICAL-ACTIVITY; LIPID-METABOLISM; BOGALUSA HEART; HYPOPITUITARY ADULTS; REPLACEMENT THERAPY; SERUM-CHOLESTEROL;
Keywords:
acute lymphoblastic leukemia; survivors; longterm; cardiovascular disease; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Oeffinger, KC Univ Texas, SW Med Ctr, Dept Family Practice & Community Med, After Canc Experience Young Adult Program, 6263 Harry Hines Blvd, Dallas,TX 75390 USA Univ Texas 6263 Harry Hines Blvd Dallas TX USA 75390 390 USA
Citazione:
K.C. Oeffinger et al., "Cardiovascular risk factors in young adult survivors of childhood acute lymphoblastic leukemia", J PED H ONC, 23(7), 2001, pp. 424-430

Abstract

Purpose: To assess cardiovascular risk factors (CVRF) in young adult survivors of childhood acute lymphoblastic leukemia (ALL). Patients and Methods: Twenty-six subjects (median age, 20.9 years: median interval since completion of therapy, 13.3 years) were evaluated. Ten participants had received cranial irradiation (CRT), whereas 16 had received only chemotherapy. Primary outcome measures included body mass index (BMI), blood pressure, fasting lipoprotein, glucose, and insulin levels. Secondary measures included insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 levels, physical activity index, a 7-day dietary recall, tobacco product use. and measurement of the intima-media thickness (IMT) of the common carotid artery. Results: Sixty-two percent (16/26) of participants had at least one CVRF potentially related to their cancer treatment (obesity, dyslipidemia, increased blood pressure, or insulin resistance), with 30% (7/26) having more than two CVRF. Thirty-one percent (8/26) of subjects were obese (BMI greater than or equal to 30). Subjects who were treated with CRT (BMI 30.4 +/- 6.7) had an increased BMI (P = 0.039) in comparison with those who received onlychemotherapy (BMI, 25.4 +/- 5.1). Triglyceride and very low-density lipoprotein C levels were significantly higher in those treated with CRT (P = 0.027 and 0.022, respectively). The IGF-1 was inversely correlated with IMT (total group, -0.514, P = 0.009: females only, -0.729. P = 0.003). Conclusions: Young adult survivors of childhood ALL, especially those treated with CRT. are at risk for obesity and dyslipidemia. insulin resistance,hypertension, and cardiovascular disease. Further investigation of these risks is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:23:15