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Titolo:
Prefrontal cortical representation of visuospatial working memory in monkeys examined by local inactivation with muscimol
Autore:
Sawaguchi, T; Iba, M;
Indirizzi:
Hokkaido Univ, Sch Med, Neurobiol Lab, Kita Ku, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan Japan Sci & Technol, Core Res Evolut Sci & Technol, Saitama 3320012, JapanJapan Sci & Technol Saitama Japan 3320012 echnol, Saitama 3320012, Japan
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 2041 - 2053
SICI:
0022-3077(200110)86:4<2041:PCROVW>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL EYE FIELD; MODULAR ORGANIZATION; ASSOCIATION CORTEX; NEURONAL-ACTIVITY; PREMOTOR CORTEX; MACAQUE MONKEY; RHESUS-MONKEYS; CONNECTIONS; AREA; TASK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Sawaguchi, T Hokkaido Univ, Sch Med, Neurobiol Lab, Kita Ku, N15 W7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ N15 W7 Sapporo Hokkaido Japan 0608638 38, Japan
Citazione:
T. Sawaguchi e M. Iba, "Prefrontal cortical representation of visuospatial working memory in monkeys examined by local inactivation with muscimol", J NEUROPHYS, 86(4), 2001, pp. 2041-2053

Abstract

In primates, dorsolateral areas of the prefrontal cortex (PFC) play a major role in visuospatial working memory. To examine the functional organization of the PFC for representing visuospatial working memory, we produced reversible local inactivation, with the local injection of muscimol (5 mug, 1 mul), at various sites (n = 100) in the dorsolateral PFC of monkeys and observed the behavioral consequences in an oculomotor delayed-response task that required memory-guided saccades for locations throughout both visual fields. At 82 sites, the local injection of muscimol induced deficits in memory-guided saccades to a few specific, usually contralateral, target locations that varied with the location of the injection site. Such deficits depended on the delay length, and longer delays were associated with larger deficits in memory-guided saccades. The injection sites and affected spatial locations of the target showed a gross topographical relationship. No deficitsappeared for a control task in which the subject was required to make a visually guided saccade to a visible target. These findings suggest that a specific site in the dorsolateral PFC is responsible for the working memory process for a specific visuospatial coordinate to guide goal-directed behavior. Further, memoranda for specific visuospatial coordinates appear to be represented in a topographical memory map within the dorsolateral PFC to represent visuospatial working memory processes.

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Documento generato il 04/04/20 alle ore 10:15:19