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Titolo:
Responses to task-irrelevant visual features by primate prefrontal neurons
Autore:
Lauwereyns, J; Sakagami, M; Tsutsui, KI; Kobayashi, S; Koizumi, M; Hikosaka, O;
Indirizzi:
Tamagawa Univ, Brain Sci Res Ctr, Tokyo 1948610, Japan Tamagawa Univ Tokyo Japan 1948610 rain Sci Res Ctr, Tokyo 1948610, Japan Juntendo Univ, Dept Physiol, Tokyo 1130033, Japan Juntendo Univ Tokyo Japan 1130033 iv, Dept Physiol, Tokyo 1130033, Japan Nihon Univ, Dept Physiol, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Univ, Dept Physiol, Tokyo 1738610, Japan Univ Tokyo, Dept Neurol, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 Tokyo, Dept Neurol, Tokyo 1138655, Japan
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 2001 - 2010
SICI:
0022-3077(200110)86:4<2001:RTTVFB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRONTAL EYE FIELD; NEURAL ACTIVITY; RHESUS-MONKEYS; UNIT-ACTIVITY; CORTEX; SELECTION; REPRESENTATION; DECISION; MACAQUE; DISCRIMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Sakagami, M Tamagawa Univ, Brain Sci Res Ctr, Tamagawa Gakuen 6-1-1, Tokyo1948610, Japan Tamagawa Univ Tamagawa Gakuen 6-1-1 Tokyo Japan 1948610 Japan
Citazione:
J. Lauwereyns et al., "Responses to task-irrelevant visual features by primate prefrontal neurons", J NEUROPHYS, 86(4), 2001, pp. 2001-2010

Abstract

The primate brain is equipped with prefrontal circuits for interpreting visual information, but how these circuits deal with competing stimulus-response (S-R) associations remains unknown. Here we show different types of responses to task-irrelevant visual features in three functionally dissociatedgroup., of primate prefrontal neurons. Two Japanese macaques participated in a go/no-go task in which they had to discriminate either the color or the motion direction of a visual target to make a correct manual response. Prior to the experiment, the monkeys had been trained extensively so that they acquired fixed associations between visual features and required responses (e.g., "green = go"; "downward motion = no-go"). In this design, the monkey was confronted with a visual target from which it had to extract relevant information (e.g., color in the color-discrimination condition) while ignoring irrelevant information (e.g., motion direction in the color-discrimination condition). We recorded from 436 task-related prefrontal neurons while the monkey performed the multidimensional go/ no-go task: 139 (32%) neurons showed go/no-go discrimination based on color as well as motion direction ("integration cells"); 192 neurons (44%) showed go/no-go discrimination only based on color ("color-feature cells"); and 105 neurons (24%) showed go/no-go discrimination only based on motion direction ("motion-feature cells"). Overall, however, 162 neurons (37%) were influenced by irrelevant information: 53 neurons (38%) among integration cells, 71 neurons (37%) among color-feature cells, and 38 neurons (36%) among motion-feature cells. Across all types of neurons, the response to an irrelevant feature was positively correlated with the response to the same feature when it was relevant, indicating that the influence from irrelevant information is a residual from S-R associations that are relevant in a different context. Temporal and anatomical differences among integration, color-feature and motion-feature cellssuggested a sequential mode of information processing in prefrontal cortex, with integration cells situated toward the output of the decision-making process. In these cells, the response to irrelevant information appears as a congruency effect, with better go/no-go discrimination when both the relevant and irrelevant feature are associated with the same response than whenthey are associated with different responses. This congruency effect couldbe the result of the combined input from color- and motion-feature cells. Thus these data suggest that irrelevant features lead to partial activationof neurons even toward the output of the decision-making process in primate prefrontal cortex.

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Documento generato il 19/01/20 alle ore 09:30:28