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Titolo:
Aging and learning-specific changes in single-neuron activity in CA1 hippocampus during rabbit trace eyeblink conditioning
Autore:
McEchron, MD; Weible, AP; Disterhoft, JF;
Indirizzi:
Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 & Mol Biol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Inst Neurosci, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 st Neurosci, Chicago, IL 60611 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 1839 - 1857
SICI:
0022-3077(200110)86:4<1839:AALCIS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; METABOTROPIC GLUTAMATE RECEPTORS; SPATIAL MEMORY TASK; RAT HIPPOCAMPUS; PYRAMIDAL NEURONS; QUANTITATIVE-ANALYSIS; AGED RATS; GABAERGIC INTERNEURONS; DORSAL HIPPOCAMPUS; QUANTAL ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: McEchron, MD Penn State Coll Med, Dept Behav Sci, 500 Univ Dr, Hershey, PA17033 USA Penn State Coll Med 500 Univ Dr Hershey PA USA 17033 7033 USA
Citazione:
M.D. McEchron et al., "Aging and learning-specific changes in single-neuron activity in CA1 hippocampus during rabbit trace eyeblink conditioning", J NEUROPHYS, 86(4), 2001, pp. 1839-1857

Abstract

Rabbit trace eyeblink conditioning is a hippocampus-dependent task in which the auditory conditioned stimulus (CS) is separated from the corneal airpuff unconditioned stimulus (US) by a 500-ms empty trace interval. Young rabbits are able to associate the CS and US and acquire trace eyeblink conditioned responses (CRs); however, a subset of aged rabbits show poor learning on this task. Several studies have shown that CA1-hippocampal activity is altered by aging; however, it is unknown how aging affects the interaction of CA1 single neurons within local ensembles during learning. The present study examined the extracellular activity of CA1 pyramidal neurons within local ensembles in aged (29-34 mo) and young (3-6 mo) rabbits during 10 daily sessions (80 trials/session) of trace eyeblink conditioning. A single surgically implanted nonmovable stereotrode was used to record ensembles rangingin size from 2 to 12 separated single neurons. A total of six young and four aged rabbits acquired significant levels of CRs, whereas five aged rabbits showed very few CRs similar to a group of five young pseudoconditioned rabbits. Pyramidal cells (2,159 total) were recorded from these four groups during training. Increases in CA1 pyramidal cell firing to the CS and US were diminished in the aged nonlearners. Local ensembles from all groups contained heterogeneous types of pyramidal cell responses. Some cells showed increases while others showed decreases in firing during the trace eyeblink trial. Hierarchical clustering was used to isolate seven different classes of single-neuron responses that showed unique firing patterns during the trace conditioning trial. The proportion of cells in each group was similar for six of seven response classes. Unlike the excitatory modeling patterns reported in previous studies, three of seven response types (67% of recorded cells) exhibited some type of inhibitory decrease to the CS, US, or both. The single-neuron response classes showed different patterns of learning-related activity across training. Several of the single-neuron types from the aged nonlearners showed unique alterations in response magnitude to the CS and US. Cross-correlation analyses suggest that specific single-neuron types provide more correlated single-neuron activity to the ensemble processingof information. However, aged nonlearners, showed a significantly lower level of coincident pyramidal cell firing for all cell types within local ensembles in CA1.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:47:04