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Titolo:
Change in neuronal firing patterns in the process of motor command generation for the ocular following response
Autore:
Takemura, A; Inoue, Y; Gomi, H; Kawato, M; Kawano, K;
Indirizzi:
Natl Inst Adv Ind Sci & Technol, Electrotech Lab, Neurosci Res Inst, Tsukuba, Ibaraki 3058568, Japan Natl Inst Adv Ind Sci & Technol Tsukuba IbarakiJapan 3058568 8568, Japan Japan Sci & Technol, Core Res Evolutional Sci & Technol, Tsukuba, Ibaraki 3058568, Japan Japan Sci & Technol Tsukuba Ibaraki Japan 3058568 Ibaraki 3058568, Japan Nippon Telegraph & Tel Publ Corp, NTT Commun Sci Labs, Kanagawa 2430198, Japan Nippon Telegraph & Tel Publ Corp Kanagawa Japan 2430198 a 2430198, Japan Adv Telecommun Res Inst Int, Kyoto 6190288, Japan Adv Telecommun Res Inst Int Kyoto Japan 6190288 nt, Kyoto 6190288, Japan
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 1750 - 1763
SICI:
0022-3077(200110)86:4<1750:CINFPI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOLATERAL PONTINE NUCLEUS; PURSUIT EYE-MOVEMENTS; CEREBELLAR VENTRAL PARAFLOCCULUS; RAPID BEHAVIORAL MODIFICATION; ALERT MONKEY; PURKINJE-CELLS; PRIMATE FLOCCULUS; HORSERADISH-PEROXIDASE; VESTIBULOOCULAR REFLEX; SMOOTH-PURSUIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Takemura, A AIST, Neurosci Res Inst, 1-1-1 Umezono, Tsukuba, Ibaraki 3058568, Japan AIST 1-1-1 Umezono Tsukuba Ibaraki Japan 3058568 058568, Japan
Citazione:
A. Takemura et al., "Change in neuronal firing patterns in the process of motor command generation for the ocular following response", J NEUROPHYS, 86(4), 2001, pp. 1750-1763

Abstract

To explore the process of motor command generation for the ocular following response, we recorded the activity of single neurons in the medial superior temporal (MST) area of the cortex, the dorsolateral pontine nucleus (DLPN), and the ventral paraflocculus (VPFL) of the cerebellum of alert monkeysduring ocular following elicited by sudden movements of a large-field pattern. Using second-order linear-regression models, we analyzed the quantitative relationships between neuronal firing frequency patterns and eye movements or retinal errors specified by three parameters (position, velocity, and acceleration). We first attempted to reconstruct the temporal waveform ofeach neuronal response to each visual stimulus and computed the coefficients for each parameter using the least-square error method for each stimuluscondition. The temporal firing patterns were generally well reconstructed [coefficient of determination index (CD) >0.7] from either the retinal error or the associated ocular following response. In the MST and DLPN datasets, however, the fit with the retinal error model was generally better than with the eye-movement model, and the estimated coefficients of acceleration and velocity ranged widely, indicating that temporal patterns in these regions showed considerable diversity. The acceleration component is greater inMST and DLPN than in VPFL, suggesting that an integration occurs in this pathway. When we determined how well the temporal patterns of the neuronal responses of a given cell could be reconstructed for all visual stimuli using a single set of coefficients, good fits were found only for Purkinje cells (P-cells) in the VPFL using the eye-movement model. In these cases, the coefficients of acceleration and velocity for each cell were similar, and the mean ratio of the acceleration and velocity coefficients was close to that of motor neurons. These results indicate that individual MST and DLPN neurons are each encoding some selective aspects of the sensory stimulus (visual motion), whereas the P-cells in VPFL are encoding the complete dynamic command signals for the associated motor response (ocular following). We conclude that the sensory-to-motor transformation for the ocular following response occurs at the P-cells in VPFL.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 22:46:02