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Titolo:
Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex
Autore:
Jin, XT; Beaver, CJ; Ji, QH; Daw, NW;
Indirizzi:
Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ol & Visual Sci, New Haven, CT 06520 USA
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 1622 - 1631
SICI:
0022-3077(200110)86:4<1622:EOTGIM>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIATES NMDA RESPONSES; LONG-TERM POTENTIATION; MGLUR1 MUTANT MICE; SYNAPTIC TRANSMISSION; NEOCORTICAL NEURONS; CRITICAL PERIOD; RECEPTORS; ACTIVATION; CAT; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Daw, NW Yale Univ, Sch Med, Dept Ophthalmol & Visual Sci, 330 Cedar St, New Haven,CT 06520 USA Yale Univ 330 Cedar St New Haven CT USA 06520 w Haven,CT 06520 USA
Citazione:
X.T. Jin et al., "Effect of the group I metabotropic glutamate agonist DHPG on the visual cortex", J NEUROPHYS, 86(4), 2001, pp. 1622-1631

Abstract

Metabotropic glutamate receptors have a variety of effects in visual cortex that depend on the age of the animal, the layer of the cortex, and the group of the receptor, Here we describe these effects for group I receptors, using both in vivo and in vitro preparations. The metabotropic group 1 glutamate receptor agonist 3,5 dihydroxyphenylglycine (DHPG) potentiates the responses to N-methyl-D-aspartate (NMDA) and alpha -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in slices of rat visual cortex. It also increases, initially, the visual response in the cat visual cortex. Both these effects are largest at 3-4 wk of age and decline to insignificance by 10 wk of age. Both are also largest in lower layers of cortex, which explains why the facilitatory effects found with the general metabotropic glutamate agonist 1S, 3R aminocyclopentane-1,3-dicarboxylic acid (ACPD) are observed only in lower layers. Prolonged application of DHPG in the cat visual cortex, after the initial excitatory effect, produces depression. We also found that DHPG facilitates the NMDA response in fast-spiking cells, which are inhibitory, providing a partial explanation for this. Thus there are multipleeffects of group I metabotropic glutamate receptors, which vary with layerand age in visual cortex.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:29:12