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Titolo:
Parallel increases in lipid and protein oxidative markers in several mousebrain regions after methamphetamine treatment
Autore:
Gluck, MR; Moy, LY; Jayatilleke, E; Hogan, KA; Manzino, L; Sonsalla, PK;
Indirizzi:
Bronx Vet Med Ctr, Dept Neurol, Bronx, NY 10468 USA Bronx Vet Med Ctr Bronx NY USA 10468 tr, Dept Neurol, Bronx, NY 10468 USA CUNY Mt Sinai Sch Med, New York, NY 10029 USA CUNY Mt Sinai Sch Med New York NY USA 10029 h Med, New York, NY 10029 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Neurol, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey Piscataway NJ USA 08854 scataway, NJ 08854 USA
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 79, anno: 2001,
pagine: 152 - 160
SICI:
0022-3042(200110)79:1<152:PIILAP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISMUTASE TRANSGENIC MICE; MITOCHONDRIAL COMPLEX-I; STRIATAL DOPAMINE; FREE-RADICALS; INDUCED NEUROTOXICITY; PARKINSONS-DISEASE; TOXICITY; DAMAGE; HYPERTHERMIA; AMPHETAMINE;
Keywords:
dopamine; methamphetamine; neurotoxicity; protein carbonyls; serotonin; TBARs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Gluck, MR Bronx Vet Med Ctr, Dept Neurol, Med Res Bldg,130 W Kingsbridge Rd, Bronx, NY 10468 USA Bronx Vet Med Ctr Med Res Bldg,130 W Kingsbridge Rd Bronx NY USA 10468
Citazione:
M.R. Gluck et al., "Parallel increases in lipid and protein oxidative markers in several mousebrain regions after methamphetamine treatment", J NEUROCHEM, 79(1), 2001, pp. 152-160

Abstract

The neurotoxic actions of methamphetamine (METH) may be mediated in part by reactive oxygen species (ROS). Methamphetamine administration leads to increases in ROS formation and lipid peroxidation in rodent brain; however, the extent to which proteins may be modified or whether affected brain regions exhibit similar elevations of lipid and protein oxidative markers have not been investigated. In this study we measured concentrations of TBARs, protein carbonyls and monoamines in various mouse brain regions at 4 h and 24h after the last of four injections of METH (10 mg/kg/injection q 2 h). Substantial increases in TBARs and protein carbonyls were observed in the striatum and hippocampus but not the frontal cortex nor the cerebellum of METH-treated mice. Furthermore, lipid and protein oxidative markers were highlycorrelated within each brain region. In the hippocampus and striatum elevations in oxidative markers were significantly greater at 24 h than at 4 h. Monoamine levels were maximally reduced within 4 h (striatal dopamine [DA] by 95% and serotonin [5-HT] in striatum, cortex and hippocampus by 60-90%). These decrements persisted for 7 days after METH, indicating effects reflective of nerve terminal damage. Interestingly, NE was only transiently depleted in the brain regions investigated (hippocampus and cortex), suggestinga pharmacological and non-toxic action of METH on the noradrenergic nerve terminals. This study provides the first evidence for concurrent formation of lipid and protein markers of oxidative stress in several brain regions of mice that are severely affected by large neurotoxic doses of METH. Moreover, the differential time course for monoamine depletion and the elevationsin oxidative markers indicate that the source of oxidative stress is not derived directly from DA or 5-HT oxidation.

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Documento generato il 28/01/20 alle ore 21:04:17