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Titolo:
Antidepressant drug treatments induce glial cell line-derived neurotrophicfactor (GDNF) synthesis and release in rat C6 glioblastoma cells
Autore:
Hisaoka, K; Nishida, A; Koda, T; Miyata, M; Zensho, H; Morinobu, S; Ohta, M; Yamawaki, S;
Indirizzi:
Natl Kure Med Ctr, Inst Clin Res, Dept Psychiat & Neurosci, Kure 7370023, Japan Natl Kure Med Ctr Kure Japan 7370023 iat & Neurosci, Kure 7370023, Japan Hiroshima Univ, Sch Med, Dept Psychiat & Neurosci, Hiroshima, Japan Hiroshima Univ Hiroshima Japan pt Psychiat & Neurosci, Hiroshima, Japan Kobe Pharmaceut Univ, Dept Clin Chem, Kobe, Hyogo, Japan Kobe Pharmaceut Univ Kobe Hyogo Japan Dept Clin Chem, Kobe, Hyogo, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 1, volume: 79, anno: 2001,
pagine: 25 - 34
SICI:
0022-3042(200110)79:1<25:ADTIGC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBGENUAL PREFRONTAL CORTEX; MOOD DISORDERS; MESSENGER-RNA; MOTOR-NEURONS; IN-VIVO; EXPRESSION; BRAIN; DEPRESSION; ASTROCYTES; STRESS;
Keywords:
amitriptyline; clomipramine; fluoxetine; GDNF; mianserin; proxetine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Hisaoka, K Natl Kure Med Ctr, Inst Clin Res, Dept Psychiat & Neurosci, 3-1Aoyama, Kure 7370023, Japan Natl Kure Med Ctr 3-1 Aoyama Kure Japan 7370023 7370023, Japan
Citazione:
K. Hisaoka et al., "Antidepressant drug treatments induce glial cell line-derived neurotrophicfactor (GDNF) synthesis and release in rat C6 glioblastoma cells", J NEUROCHEM, 79(1), 2001, pp. 25-34

Abstract

Modulation of neurotrophic factors to protect neurons from damage is proposed as a novel mechanism for the action of antidepressants. However, the effect of antidepressants on modulation of glial cell line-derived neurotrophic factor (GDNF), which has potent and widespread effects, remains unknown. Here, we demonstrated that long-term use of antidepressant treatment significantly increased GDNF mRNA expression and GDNF release in time- and concentration-dependent manners in rat C6 glioblastoma cells. Amitriptyline treatment also increased GDNF mRNA expression in rat astrocytes. GDNF release continued for 24 h following withdrawal of amitriptyline. Furthermore, following treatment with antidepressants belonging to several different classes (amitriptyline, clomipramine, mianserin, fluoxetine and paroxetine) significantly increased GDNF release, but which did not occur after treatment withnon-antidepressant psychotropic drugs (haloperidol, diazepam and diphenhydramine). Amitriptyline-induced GDNF release was inhibited by U0126 (10 muM), a mitogen-activated protein kinase (MAPK)-extra-cellular signal-related kinase (ERK) kinase (MEK) inhibitor, but was not inhibited by H-89 (muM), a protein kinase A inhibitor, calphostin C (100 nM), a protein kinase C inhibitor and PD 169316 (10 muM), a p38 mitogen-activated protein kinase inhibitor. These results suggested that amitriptyline-induced GDNF synthesis and release occurred at the transcriptional level, and may be regulated by MEK/MAPK signalling. The enhanced and prolonged induction of GDNF by antidepressants could promote neuronal survival, and protect neurons from the damagingeffects of stress. This may contribute to explain therapeutic action of antidepressants and suggest new strategies of pharmacological intervention.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 12:29:27