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Titolo:
Mouse astrocytoma models: Embryonic stem cell mediated transgenesis
Autore:
Ding, H; Guha, A;
Indirizzi:
Toronto Hosp, Western Div, Univ Hlth Network, Div Neurosurg, Toronto, ON M5T 2S8, Canada Toronto Hosp Toronto ON Canada M5T 2S8 osurg, Toronto, ON M5T 2S8, Canada Hosp Sick Children, Res Inst, Arthur & Sonia Labatts Brain Tumor Ctr, Toronto, ON M5G 1X8, Canada Hosp Sick Children Toronto ON Canada M5G 1X8 Toronto, ON M5G 1X8, Canada Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Inst, Toronto, ON M5G 1X5, Canada
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 53, anno: 2001,
pagine: 289 - 296
SICI:
0167-594X(2001)53:3<289:MAMESC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CRE RECOMBINASE; V-SRC; NEUROFIBROMATOSIS TYPE-1; GENE-EXPRESSION; T-ANTIGEN; MICE; GENOME; PROMOTER; REPORTER; PROTEIN;
Keywords:
astrocytoma; glioblastoma multiforme; transgenic models; tumor progression; embryonic stem cells; site-specific recombinase; transgenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Guha, A Toronto Hosp, Western Div, Univ Hlth Network, Div Neurosurg, 399 Bathurst St, Toronto, ON M5T 2S8, Canada Toronto Hosp 399 Bathurst St Toronto ON Canada M5T 2S8 2S8, Canada
Citazione:
H. Ding e A. Guha, "Mouse astrocytoma models: Embryonic stem cell mediated transgenesis", J NEURO-ONC, 53(3), 2001, pp. 289-296

Abstract

The development of rational and targeted therapies for human astrocytomas is heavily dependent on our knowledge of its molecular pathogenesis, combined with the generation of appropriate pre-clinical mouse models. The ability to manipulate the mouse genome, which is nearing completion and is highlyhomologous to its human counterpart, has significantly accelerated our ability to create transgenic mouse models that replicate the pathological and molecular characteristics found in human astrocytomas. These models should serve to further our knowledge of the molecular pathogenesis of human astrocytomas, and serve as useful reagents to test conventional and novel thera-break peutics.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:51:50