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Titolo:
Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: A model for experimental therapeutics of low-grade gliomas
Autore:
Kish, PE; Blaivas, M; Strawderman, M; Muraszko, KM; Ross, DA; Ross, BD; McMahon, G;
Indirizzi:
Univ Michigan, Sch Med, Dept Neurosurg, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Neurosurg, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 rehens Canc, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 Dept Radiol, Ann Arbor, MI 48109 USA Sugen Inc, S San Francisco, CA USA Sugen Inc S San Francisco CA USASugen Inc, S San Francisco, CA USA
Titolo Testata:
JOURNAL OF NEURO-ONCOLOGY
fascicolo: 3, volume: 53, anno: 2001,
pagine: 243 - 257
SICI:
0167-594X(2001)53:3<243:MRIOER>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED TRANSPLACENTAL CARCINOGENESIS; ESTER-MEDIATED INDUCTION; N-NITROSOUREA; TUMOR ANGIOGENESIS; NERVOUS-SYSTEM; CHEMOPREVENTIVE AGENTS; CEREBRAL HEMISPHERES; VITAMIN-A; ETHYLNITROSOUREA; ASTROCYTOMAS;
Keywords:
magnetic resonance imaging; ENU; transplacental induction; N-ethyl-N-nitrosourea; gliomas;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Kish, PE Univ Michigan, Sch Med, Dept Neurosurg, 1500 E Med Ctr Dr,2128 Taubman,Box0338, Ann Arbor, MI 48109 USA Univ Michigan 1500 E Med Ctr Dr,2128Taubman,Box 0338 Ann Arbor MI USA 48109
Citazione:
P.E. Kish et al., "Magnetic resonance imaging of ethyl-nitrosourea-induced rat gliomas: A model for experimental therapeutics of low-grade gliomas", J NEURO-ONC, 53(3), 2001, pp. 243-257

Abstract

Human low-grade gliomas represent a population of brain tumors that remaina therapeutic challenge. Preclinical evaluation of agents, to test their preventive or therapeutic efficacy in these tumors, requires the use of animal nobreak models. Spontaneous gliomas develop in models of chemically induced carcinogenesis, such as in the transplacental N-ethyl-N-nitrosourea (ENU) rat model. However, without the ability to detect initial tumor formation, multiplicity or to measure growth rates, it is difficult to test compounds for their interventional or preventional capabilities. In this study Fisher-334 rats, treated transplacentally with ENU, underwent magnetic resonance imaging (MRI) examination in order to evaluate this approach for detection of tumor formation and growth. ENU-induced intracranial cerebral tumors were first observable in T2-weighted images beginning at 4 months of age and grew with a mean doubling time of 0.487 +/- 0.112 months. These tumors were found histologically to be predominately mixed gliomas. Two therapeutic interventions were evaluated using MRI, vitamin A (all-trans retinol palmitate, RP), as a chemopreventative agent and the anti-angiogenic drug SU-5416. RP was found to significantly delay the time to first tumor observation by one month (P = 0.05). No differences in rates of tumor formation or growth rates were observed between control and RP-treated groups. MRI studies ofrats treated with SU-5416 resulted in reduction in tumor growth rates compared to matched controls. These results show that MRI can be used to provide novel information relating to the therapeutic efficacy of agents against the ENU-induced tumor model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:08:04