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Titolo:
Analysis of distributions of amino acids and amino acid pairs in human tumour necrosis factor precursor and its eight mutations according to a randommechanism
Autore:
Wu, G; Yan, SM;
Indirizzi:
Univ Aix Marseille 2, Fac Pharm, Lab Toxicocinet & Pharmacocinet, F-13284 Marseille 07, France Univ Aix Marseille 2 Marseille France 07 t, F-13284 Marseille 07, France Univ Udine, Fac Med & Chirurg, Dipartimento Ric Med & Morfol, Cattedra Anat Patol, I-33100 Udine, Italy Univ Udine Udine Italy I-33100 Cattedra Anat Patol, I-33100 Udine, Italy
Titolo Testata:
JOURNAL OF MOLECULAR MODELING
fascicolo: 9, volume: 7, anno: 2001,
pagine: 318 - 323
SICI:
1610-2940(2001)7:9<318:AODOAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARKOV-CHAIN ANALYSIS; CRYSTAL-STRUCTURE; ALPHA MUTANT; SEQUENCES; PROTEIN; FREQUENCY;
Keywords:
amino acids; tumour necrosis factor precursor; probability;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, G Novartis Pharma AG, DMPK, WKL-135-1-16, CH-4002 Basel, Switzerland Novartis Pharma AG WKL-135-1-16 Basel Switzerland CH-4002 itzerland
Citazione:
G. Wu e S.M. Yan, "Analysis of distributions of amino acids and amino acid pairs in human tumour necrosis factor precursor and its eight mutations according to a randommechanism", J MOL MODEL, 7(9), 2001, pp. 318-323

Abstract

In this study, we use the random principle to analyse the distributions ofamino acids and amino acid pairs in human tumour necrosis factor precursor(TNF-alpha) and its eight mutations, to compare the measured distribution probability with the theoretical distribution probability and to rank the measured distribution probability against the theoretical distribution probability. In this way, we can suggest that distributions with a high random rank should not be deliberately evolved and conserved and those with a low random rank should be deliberately evolved and conserved in human TNF-alpha. An increased distribution probability in a mutation means probabilistically that the mutation is more likely to occur spontaneously, whereas a decreased distribution probability in a mutation means probabilistically that themutation is less likely to occur spontaneously and perhaps is more relatedto a certain cause. The results, for example, show that the distributions of 30% of the amino acids are identical with their probabilistic simplest distributions, and the distributions of some of the remaining amino acids are very close to their probabilistic simplest distributions. With respect toprobabilities of distributions of amino acids in mutations, the results show that mutations lead to an increase in eight probabilities, which are thus more likely to occur. Eight probabilities decrease and are thus less likely to occur. With respect to the random ranks against the theoretical probabilities of distributions of amino acids, the results show that mutations lead to an increase in seven and a decrease in seven probabilities, with twoprobabilities unchanged.

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Documento generato il 04/04/20 alle ore 12:24:24