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Titolo:
Endothelin-1 in smooth muscle cells and mast cells of mouse uterus after parturition
Autore:
Uchide, T; Adur, J; Yoshioka, K; Sasaki, T; Temma, K; Saida, K;
Indirizzi:
Kitasato Univ, Sch Vet Med & Anim Sci, Dept Toxicol, Towada, Aomori 0348628, Japan Kitasato Univ Towada Aomori Japan 0348628 , Towada, Aomori 0348628, Japan Natl Inst Adv Ind Sci & Technol, Minist Econ Trade & Ind, Tsukuba, Ibaraki3058566, Japan Natl Inst Adv Ind Sci & Technol Tsukuba Ibaraki Japan 3058566 8566, Japan Kitasato Univ, Sch Vet Med & Anim Sci, Dept Vet Anat, Towada, Aomori 0348628, Japan Kitasato Univ Towada Aomori Japan 0348628 , Towada, Aomori 0348628, Japan
Titolo Testata:
JOURNAL OF MOLECULAR ENDOCRINOLOGY
fascicolo: 2, volume: 27, anno: 2001,
pagine: 165 - 173
SICI:
0952-5041(200110)27:2<165:EISMCA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL CONTRACTOR; HUMAN ENDOMETRIUM; GENE-EXPRESSION; BIOLOGICAL-ACTIVITY; RABBIT UTERUS; RECEPTOR; CLONING; PREGNANCY; PEPTIDE; FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Uchide, T Kitasato Univ, Sch Vet Med & Anim Sci, Dept Toxicol, 35-1 Higashi 23 Bancho, Towada, Aomori 0348628, Japan Kitasato Univ 35-1 Higashi 23 Bancho Towada Aomori Japan 0348628
Citazione:
T. Uchide et al., "Endothelin-1 in smooth muscle cells and mast cells of mouse uterus after parturition", J MOL ENDOC, 27(2), 2001, pp. 165-173

Abstract

To elucidate the physiological importance of endothelin-1 (ET-1) in mouse uterus, we investigated quantitative changes in ET-1 mRNA levels in the uterus during the estrous cycle, pregnancy and post-parturient period by use of the real-time PCR technique and we examined the cellular distribution of the ET-1 peptide by use of immunohistochemical techniques. Low and constantmRNA levels were observed in the uterus from cyclic or pregnant mice. However, a significant increase in mRNA levels was found immediately after parturition (day 0 postpartum) which then decreased gradually to a basal level at day 14 postpartum. Discernible immunopositivity was found in myometrial cells as well as in endometrial epithelial cells in the post-parturient uterus. Myometrial cells showed the strongest staining at day 0 postpartum, and some large cells in the myometrial layers, intensely positive for ET-1, were characterized as mast cells. These findings suggest the possibility that in mouse uterus ET-1 may play a role in recovery from the uterine changescaused by pregnancy and parturition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:55:28