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Titolo:
Myxobacteria, producers of novel bioactive substances
Autore:
Reichenbach, H;
Indirizzi:
Gesell Biotechnol Forsch mbH, GBF, Abt Naturstoffbiol, D-38124 Braunschweig, Germany Gesell Biotechnol Forsch mbH Braunschweig Germany D-38124 hweig, Germany
Titolo Testata:
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
fascicolo: 3, volume: 27, anno: 2001,
pagine: 149 - 156
SICI:
1367-5435(200109)27:3<149:MPONBS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BITHIAZOLE-TYPE ANTIBIOTICS; STIGMATELLA-AURANTIACA; MYXOCOCCUS-XANTHUS; CYSTOBACTER-FUSCUS; STRUCTURE ELUCIDATION; BIOLOGICAL PROPERTIES; PHYLOGENETIC ANALYSIS; ACTIN CYTOSKELETON; GLIDING BACTERIA; FRUITING BODY;
Keywords:
myxobacteria; source of natural products; electron transport inhibitors; RNA polymerase inhibitors; tubulin interaction; actin interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Reichenbach, H Gesell Biotechnol Forsch mbH, GBF, Abt Naturstoffbiol, Mascheroder Weg 1, D-38124 Braunschweig, Germany Gesell Biotechnol Forsch mbH Mascheroder Weg 1 Braunschweig Germany D-38124
Citazione:
H. Reichenbach, "Myxobacteria, producers of novel bioactive substances", J IND MIC B, 27(3), 2001, pp. 149-156

Abstract

Myxobacteria are soil bacteria that move by gliding and have an astonishing life cycle culminating in fruiting body formation. In a research program at the Gesellshaft fur Biotechnologische Forschung over the past 25 years the organisms have been shown to be a rich source of potentially useful secondary metabolites. So far about 80 different basic compounds and 450 structural variants have been characterized. Many of those compounds were new. Itis particularly remarkable that myxobacteria specialize in mechanisms of action that are very rare with other producers. Thus 20 new electron transport inhibitors, 10 substances that act on the cytoskeleton, four inhibitors of nucleic acid polymerases, and one inhibitor of fungal acetyl-CoA carboxylase, a novel mechanism of action, have been found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 20:54:41