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Titolo:
Superior 12-hour heart preservation with pinacidil hyperpolarizing solution compared to University of Wisconsin solution
Autore:
Hoenicke, EM; Damiano, RJ;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Div Cardiothorac Surg, Dept Surg, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rg, Dept Surg, Hershey, PA 17033 USA
Titolo Testata:
JOURNAL OF HEART AND LUNG TRANSPLANTATION
fascicolo: 10, volume: 20, anno: 2001,
pagine: 1106 - 1114
SICI:
1053-2498(200110)20:10<1106:S1HPWP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTASSIUM-CHANNEL OPENER; LONG-TERM PRESERVATION; ST. THOMAS SOLUTION; OF-WISCONSIN; SARCOPLASMIC-RETICULUM; REPERFUSION INJURY; PERFUSED HEART; GUINEA-PIG; CARDIOPLEGIA; CALCIUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Damiano, RJ Washington Univ, Sch Med, Div Cardiac Surg, Dept Surg, Campus Box 8234,Suite 3108,Queeny Tower,1 Barnes, St Louis, MO 63110 USA Washington Univ Campus Box 8234,Suite 3108,Queeny Tower,1 Barnes St Louis MO USA 63110
Citazione:
E.M. Hoenicke e R.J. Damiano, "Superior 12-hour heart preservation with pinacidil hyperpolarizing solution compared to University of Wisconsin solution", J HEART LUN, 20(10), 2001, pp. 1106-1114

Abstract

Background: A novel donor heart preservation solution was formulated to produce hyperpolarized arrest with the potassium channel opener, pinacidil. The superior cardioprotective efficacy of this solution has been demonstrated previously when compared to University of Wisconsin solution following 4 hours of hypothermic ischemia. This study tested the hypothesis that pinacidil solution may extend preservation time and provide superior cardioprotective efficacy following 12 hours of ischemia. Methods: Sixteen rabbit hearts were assigned to receive either pinacidil solution or University of Wisconsin solution in a crystalloid-perfused Langendorff model. Thirty minutes of initial perfusion preceded baseline data acquisition. Left ventricle pressure-volume curves were generated by inflating an intra-ventricular latex balloon. Following cardioplegic administration, hearts underwent 12 hours of hypothermic storage. After 60 minutes of reperfusion, post-ischemic data were acquired. Results: Pinacidil solution demonstrated significantly better myocardial preservation compared to University of Wisconsin solution, with better recovery of developed pressure (53.0 +/- 11.1% vs 20.7 +/- 4.3%, p = 0.017, respectively), post-ischemic coronary flow (55.3 +/- 12.6% vs 23.9 +/- 4.3%, p = 0.034), maximum systolic dP/dT (46.4 +/- 8.3% vs 20.2 +/- 5.1%, p = 0.018) and minimum diastolic -dP/dT (65.3 +/- 10.8% vs 20.2 +/- 5.1%, p = 0.002). Diastolic compliance, expressed as baseline/post-ischemic diastolic sloperatios, was also better preserved by pinacidil solution (0.55 +/- 0.09) vsUniversity of Wisconsin solution (0.40 +/- 0.03) (p = 0.135). Conclusions: A novel pinacidil solution resulted in improved donor heart preservation during 12 hours of hypothermic ischemia compared to the "gold standard," University of Wisconsin solution. Adopting alternative strategiesof hyperpolarized arrest may allow extension of preservation time beyond the limits of traditional depolarizing solutions.

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Documento generato il 31/03/20 alle ore 03:37:41