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Titolo:
The gut and food intake: An update for surgeons
Autore:
Naslund, E; Hellstrom, PM; Kral, JG;
Indirizzi:
Danderyd Hosp, Karolinska Inst, Div Surg, Stockholm, Sweden Danderyd HospStockholm Sweden linska Inst, Div Surg, Stockholm, Sweden Karolinska Hosp, Dept Gastroenterol & Hepatol, S-10401 Stockholm, Sweden Karolinska Hosp Stockholm Sweden S-10401 atol, S-10401 Stockholm, Sweden Suny Downstate Med Ctr, Dept Surg, Brooklyn, NY 11203 USA Suny Downstate Med Ctr Brooklyn NY USA 11203 Surg, Brooklyn, NY 11203 USA
Titolo Testata:
JOURNAL OF GASTROINTESTINAL SURGERY
fascicolo: 5, volume: 5, anno: 2001,
pagine: 556 - 567
SICI:
1091-255X(200109/10)5:5<556:TGAFIA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; POSITRON-EMISSION-TOMOGRAPHY; VAGAL AFFERENT RESPONSES; GASTRIC-ACID SECRETION; RAT VAGUS NERVE; MORBID-OBESITY; BINDING-SITES; ENERGY-INTAKE; BODY-WEIGHT; POSTPRANDIAL SATIATION;
Keywords:
appetite regulation; gastrointestinal surgery; neurogastroenterology; glucagon-like peptide-1; cholecystokinin; vagus nerve;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
146
Recensione:
Indirizzi per estratti:
Indirizzo: Naslund, E Danderyd Hosp, Dept Surg, SE-18288 Danderyd, Sweden Danderyd Hosp Danderyd Sweden SE-18288 18288 Danderyd, Sweden
Citazione:
E. Naslund et al., "The gut and food intake: An update for surgeons", J GASTRO S, 5(5), 2001, pp. 556-567

Abstract

Food intake is the simplest and most obvious measure of gastrointestinal function, yet it rarely receives more than cursory attention from surgeons. In this review we cover recent findings on relationships between gut function and appetite regulation mediated via neuropeptides influenced by afferent and efferent vagal activity. Evidence from the new discipline known as neurogastroenterology elucidates gastric and intestinal signals involved in the elicitation of hunger, satiety, and aversion. Discovery of the adipose-tissue-derived hormone, leptin, has energized the field of metabolism spawning increasing numbers of publications related to interactions between leptin and insulin release and glucose disposal, as well as appetitive behavior. Peptides such as cholecystokinin (CCK), the proglucagon-derived peptides, glucagon-like peptides 1 and 2 (GLP-1 and GL-2), and the recently identified powerful intake-stimulating molecule, orexin, are examples of potential targets for drug development and studies of surgical pathophysiology. A major conclusion of this work is that the considerable redundancy and overlap between mediators of caloric intake subserving survival of the species, while beneficial after foregut surgery, contribute to the complexity of treating the global epidemic of obesity. Possibly knowledge derived from basic research in neurogastroenterology can translate into advances in surgical treatment of obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:53:18