Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Preoperative intraluminal application of capsaicin increases postoperativegastric and colonic motility in rats
Autore:
Zittel, TT; Meile, T; Huge, A; Kreis, ME; Becker, HD; Jehle, EC;
Indirizzi:
Univ Hosp, Dept Gen & Transplantat Surg, D-72076 Tubingen, Germany Univ Hosp Tubingen Germany D-72076 antat Surg, D-72076 Tubingen, Germany
Titolo Testata:
JOURNAL OF GASTROINTESTINAL SURGERY
fascicolo: 5, volume: 5, anno: 2001,
pagine: 503 - 513
SICI:
1091-255X(200109/10)5:5<503:PIAOCI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; SUBSTANCE-P; SENSORY NEURONS; GASTROINTESTINAL TRANSIT; SPINAL AFFERENTS; AWAKE RATS; ILEUS; CALCITONIN; CGRP; MECHANISMS;
Keywords:
postoperative ileus; visceral afferent nerve fibers; capsaicin; gastric motility; small intestinal motility; colonic motility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Zittel, TT Univ Hosp, Dept Gen & Transplantat Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany Univ Hosp Hoppe Seyler Str 3 Tubingen Germany D-72076 Germany
Citazione:
T.T. Zittel et al., "Preoperative intraluminal application of capsaicin increases postoperativegastric and colonic motility in rats", J GASTRO S, 5(5), 2001, pp. 503-513

Abstract

In a model to investigate postoperative gastrointestinal motility with strain gauge transducers in awake rats, we tested the effects of intraluminal capsaicin infusion into the cecum 2 days or 14 days prior to abdominal surgery Acute infusion of capsaicin into the cecum for 30 minutes increased thegastric, small intestinal, and colonic motility index by up to 115%, 34%, and 59%, respectively, compared to vehicle infusion. Intraluminal capsaicininfusion 2 days prior to abdominal surgery significantly increased the intraoperative gastric and colonic motility index by 166% and 100%, respectively, compared to vehicle, but had no effect on small intestinal motility Thepostoperative decrease in gastric or colonic motility was completely prevented by capsaicin pretreatment, representing a 73% and a 72% increase in the motility index during the first postoperative hour and a 40% and a 29% increase in the motility index during the second postoperative hour compared to vehicle, whereas the postoperative decrease in small intestinal motilitywas not altered by capsaicin pretreatment. In contrast, intraluminal capsaicin infusion 14 days prior to abdominal surgery had no effect on postoperative inhibition of gastrointestinal motility. Our results suggest that capsaicin-sensitive visceral afferent C-fibers, presumably of the submucosa, piav an important role in mediating postoperative ileus. Intraluminal capsaicin does probably ablate these nerve fibers temporarily, with no systemic side effects observed with the use of the tail flick test as a measure of skin nociception.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 21:20:57