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Titolo:
Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum
Autore:
Raza, M; Shaheen, F; Choudhary, MI; Sombati, S; Rafiq, A; Suria, A; Rahman, A; DeLorenzo, RJ;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA Univ Karachi, Int Ctr Res Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan Univ Karachi Karachi Pakistan 75270 s Inst Chem, Karachi 75270, Pakistan Aga Khan Univ, Coll Med, Dept Physiol & Pharmacol, Karachi 74800, PakistanAga Khan Univ Karachi Pakistan 74800 Pharmacol, Karachi 74800, Pakistan Virginia Commonwealth Univ, Med Coll Virginia, Dept Biochem & Mol Biophys,Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 s,Richmond, VA 23298 USA Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
JOURNAL OF ETHNOPHARMACOLOGY
fascicolo: 1, volume: 78, anno: 2001,
pagine: 73 - 78
SICI:
0378-8741(200111)78:1<73:AAOEEA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIEPILEPTIC DRUG DEVELOPMENT; PHARMACOLOGICAL FACTORS; LABORATORY EVALUATION; SEIZURE MODELS; TOXICITY;
Keywords:
Delphinium denudatum; medicinal plants; anticonvulsant activity; maximal electroshock; pentyleneterazole; bicuculline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: DeLorenzo, RJ Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurol, POB 980599, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980599 Richmond VA USA 23298
Citazione:
M. Raza et al., "Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum", J ETHNOPHAR, 78(1), 2001, pp. 73-78

Abstract

Dried roots of Delphinium denudatum Wall. are a popular folk remedy for the treatment of epilepsy in the traditional Unani system of medicine in the sub-continent. We carried out anticonvulsant screening of the ethanolic extract (EE) and aqueous fraction (AF) of this plant utilising the maximal electroshock (MEST) and subcutaneous pentylenetetrazole (scPTZ), bicuculline (scBIC), picrotoxin (scPTX) and strychnine (scSTN) tests for anticonvulsant activity. EE had weak dose-dependent anticonvulsant effects on seizures induced by PTZ and BIC. AF exhibited dose-dependent activity against hind limbtonic extension phase (HLTE) of MEST and comparatively stronger anticonvulsant activity against seizures induced by PTZ and BIC. The results suggest the presence of potent anticonvulsant compounds in AF of D. denudatum and deserve further investigation for isolation of active compounds and elucidation of the mechanism of anticonvulsant action. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:12:57