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Titolo:
Longitudinal profiles of semantic impairment for living and nonliving concepts in dementia of Alzheimer's type
Autore:
Garrard, P; Ralph, MAL; Watson, PC; Powis, J; Patterson, K; Hodges, JR;
Indirizzi:
Natl Hosp Neurol & Neurosurg, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England Univ Bristol, Bristol BS8 1TH, Avon, England Univ Bristol Bristol Avon England BS8 1TH Bristol BS8 1TH, Avon, England MRC, Cognit & Brain Sci Unit, Cambridge, England MRC Cambridge EnglandMRC, Cognit & Brain Sci Unit, Cambridge, England
Titolo Testata:
JOURNAL OF COGNITIVE NEUROSCIENCE
fascicolo: 7, volume: 13, anno: 2001,
pagine: 892 - 909
SICI:
0898-929X(200110)13:7<892:LPOSIF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATEGORY-SPECIFIC DEFICITS; COMPUTATIONAL ACCOUNT; SELECTIVE IMPAIRMENT; KNOWLEDGE; DISEASE; MEMORY; DISSOCIATION; SYSTEMS; ACCESS; THINGS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Garrard, P Inst Cognit Neurosci, Alexandra House,17 Queen Sq, London WC1N 3AR, England Inst Cognit Neurosci Alexandra House,17 Queen Sq London England WC1N 3AR
Citazione:
P. Garrard et al., "Longitudinal profiles of semantic impairment for living and nonliving concepts in dementia of Alzheimer's type", J COGN NEUR, 13(7), 2001, pp. 892-909

Abstract

Two types of theoretical account have been proposed to explain the phenomenon of category-specific impairment in tests of semantic memory: One stresses the importance of different cortical regions to the representation of living and nonliving categories, while the other emphasize the importance of statistical relationships among features of concepts belonging to these twobroad semantic domains. Theories of the latter kind predict that the direction of a domain advantage will be determined in large part by the overall damage to the semantic system, and that the profiles of patients with progressive impairments of semantic memory are likely to include a point at which an advantage for one domain changes to an advantage for the other. The present series of three studies employed semantic test data from two separatecohorts of patients with probable dementia of Alzheimer's type (DAT) to look for evidence of such a crossover. In the first study, longitudinal test scores from a cohort of 58 patients were examined to confirm the presence of progressive semantic deterioration in this group. In the second study, Kaplan-Meier survival curves based on serial naming responses and plotted separately for items belonging to living and nonliving domains indicated that the representations of living concepts (as measured by naming) deterioratedat a consistently and significantly faster rate than those of nonliving concepts. A third study, carried out to look in detail at the performance of mildly affected patients, employed an additional cross-sectional cohort of 20 patients with mild DAT and utilized a graded naming assessment. This study also revealed no evidence for a crossover in the advantage of one domainover the other as a function of disease severity. Taken together with the model of anatomical progression in DAT based on the work of Braak and Braak(1991), these findings are interpreted as evidence for the importance of regional cerebral anatomy to the genesis of semantic domain effects in DAT.

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Documento generato il 25/11/20 alle ore 06:42:08