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Titolo:
Lipid rafts and HIV-1: from viral entry to assembly of progeny virions
Autore:
Campbell, SM; Crowe, SM; Mak, J;
Indirizzi:
Macfarlane Burnet Ctr Med Res, AIDS Pathogenesis Res Unit, Fairfield, Vic 3078, Australia Macfarlane Burnet Ctr Med Res Fairfield Vic Australia 3078078, Australia Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Monash Univ, Dept Med, Prahran, Vic 3181, Australia Monash Univ Prahran Vic Australia 3181 Med, Prahran, Vic 3181, Australia Natl Ctr HIV Virol Res, Fairfield, Vic 3078, Australia Natl Ctr HIV Virol Res Fairfield Vic Australia 3078 , Vic 3078, Australia Monash Univ, Dept Biochem & Mol Biol, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Biol, Clayton, Vic 3168, Australia
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 3, volume: 22, anno: 2001,
pagine: 217 - 227
SICI:
1386-6532(200110)22:3<217:LRAHFV>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PROTEIN-TYROSINE KINASES; SEMLIKI-FOREST-VIRUS; LYMPHOCYTE PLASMA-MEMBRANES; CAVEOLAE-LIKE DOMAINS; CLASS-I MOLECULES; HUMAN T-CELLS; NEF PROTEIN; INTERMEDIATE COMPLEXES; CHOLESTEROL DEPLETION;
Keywords:
lipid rafts; HIV-1; cholesterol; caveolin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
98
Recensione:
Indirizzi per estratti:
Indirizzo: Mak, J Macfarlane Burnet Ctr Med Res, AIDS Pathogenesis Res Unit, Fairfield, Vic 3078, Australia Macfarlane Burnet Ctr Med Res Fairfield Vic Australia 3078 stralia
Citazione:
S.M. Campbell et al., "Lipid rafts and HIV-1: from viral entry to assembly of progeny virions", J CLIN VIRO, 22(3), 2001, pp. 217-227

Abstract

Background: Lipid rafts are currently an intensely investigated topic of cell biology. In addition to a demonstrated role in signal transduction. of the host cell, lipid rafts serve as entry and exit sites for microbial pathogens and toxins, such as FimH-expressing enterobacteria, influenza virus, measles virus and cholera toxin. Furthermore, caveolae, a specialised form of lipid raft, are required for the conversion of the non-pathogenic prion protein to the pathogenic scrapie isoform. Objectives: A number of reports have shown, directly or indirectly, that lipid rafts are important at various stages of the human immunodeficiency virus type-1 (HIV-1) replication cycle. The purpose of this paper is to provide a brief overview of the role of membrane-associated lipid rafts in cell biology, and to evaluate how HIV-1 has hijacked this cellular component to support HIV-1 replication. Special sections are devoted to discussing the role of lipid rafts in (1) the entry of HIV-1, (2) signal transduction regulation in HIV-1-infected cells, (3) the trafficking of HIV-1 proteins via lipid rafts during HIV-1 assembly; and a further section discusses the role of cholesterol in mature HIV-1. Summary: Like a number of other pathogens, HIV-1 has evolved to rely on the host cell lipid rafts to support its propagation during multiple stages of the HIV-1 replication cycle. This review has highlighted the importance of lipid rafts in HIV-1 replication. (C) 2001 Elsevier Science BY. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:50:34