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Titolo:
Role of CCR5, CCR2 and SDF-1 gene polymorphisms in a population of HIV-1 infected individuals
Autore:
Mazzucchelli, R; Corvasce, S; Violin, M; Riva, C; Bianchi, R; Deho, L; Velleca, R; Cibella, J; Bada, M; Moroni, M; Galli, M; Balotta, C;
Indirizzi:
Univ Milan, Inst Infect & Trop Dis, Milan, Italy Univ Milan Milan ItalyUniv Milan, Inst Infect & Trop Dis, Milan, Italy
Titolo Testata:
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 265 - 271
SICI:
0393-974X(200107/09)15:3<265:ROCCAS>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISEASE PROGRESSION; DELETION ALLELE; CLINICAL COURSE; AIDS; RESISTANCE; CCR5-DELTA-32; TRANSMISSION; VIRUS; RESTRICTION; PROGNOSIS;
Keywords:
CCR5-Delta 32; CCR2-641; SDFI-3 ' A; HIV-1 genomic RNA; US and MS intracellular specific transcripts; LTNPs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Mazzucchelli, R Univ Milan, Osped L Sacco, Ist Malattie Infett & Trop, ViaGB Grossi 74, I-20157 Milan, Italy Univ Milan Via GB Grossi 74 Milan Italy I-20157 an, Italy
Citazione:
R. Mazzucchelli et al., "Role of CCR5, CCR2 and SDF-1 gene polymorphisms in a population of HIV-1 infected individuals", J BIOL REG, 15(3), 2001, pp. 265-271

Abstract

The finding that in addition to CD4 molecule HIV-1 uses, CCR5 or CXCR4 receptors to enter target cells prompted the research to identify polymorphisms in coreceptor genes affecting disease progression. In this study we analyzed the prevalence of CCR5-Delta 32, CCR2-641 and SDF1-3'A alleles in a highly selected group of 42 Long-Term Nonprogressors (LTNPs) compared to 112 subjects with a typical course of HIV-1 infection (TPs) and 117 healthy controls (HCs). In addition, we correlated CCR5, CCR2 and SDF-1 genotypes with molecular indexes of HIV-1 replication, cell-free RNA and both unspliced (US) and multiply spliced (MS) intracellular transcripts, to investigate the role of the mutant alleles in determining a long-term nonprogressive courseof HIV-1 disease. Our results indicate a significantly higher prevalence of CCR5-Delta 32 allele in LTNPs compared to TPs (p = 0.0434), while the proportions of CCR2-641 and SDF1-3'A alleles were comparable between the two groups. However, SDF-1 wild type LTNP subjects showed significantly lower levels of HIV-1 genomic RNA, US and MS transcripts than SDF1-3'A heterozygousones (p = 0.0021, 0.016, 0.0031, respectively), whereas both CCR5 and CCR2wild type individuals had similar rates of viral replication compared to CCR5-Delta 32 and CCR2-641 heterozygous ones. CCR5, CCR2 and SDF-1 combined genotypes were also studied and this analysis did not identify a specific protective cluster of alleles in LTNPs. Taken together, our results indicatethat genetic background involving CCR5, CCR2 and SDF-1 alleles may play a limited role in the natural history of HIV-1 infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:40:42