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Titolo:
Morphine metabolism in the opium poppy and its possible physiological function - Biochemical characterization of the morphine metabolite, bismorphine
Autore:
Morimoto, S; Suemori, K; Moriwaki, J; Taura, F; Tanaka, H; Aso, M; Tanaka, M; Suemune, H; Shimohigashi, Y; Shoyama, Y;
Indirizzi:
Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 Pharmaceut Sci, Fukuoka 8128582, Japan Kyushu Univ, Fac & Grad Sch Sci, Fukuoka 8128581, Japan Kyushu Univ Fukuoka Japan 8128581 & Grad Sch Sci, Fukuoka 8128581, Japan
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 41, volume: 276, anno: 2001,
pagine: 38179 - 38184
SICI:
0021-9258(20011012)276:41<38179:MMITOP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCUTELLARIA-BAICALENSIS-GEORGI; PLANT-CELL WALLS; DIFERULIC ACID; PEROXIDASE; PROTEIN; PURIFICATION; GENERATION; INFECTION; CULTURES; OXYGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Morimoto, S Kyushu Univ, Grad Sch Pharmaceut Sci, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ci, Fukuoka 8128582, Japan
Citazione:
S. Morimoto et al., "Morphine metabolism in the opium poppy and its possible physiological function - Biochemical characterization of the morphine metabolite, bismorphine", J BIOL CHEM, 276(41), 2001, pp. 38179-38184

Abstract

We identified a novel metabolic system of morphine in the opium poppy (Papaver somniferum L.). In response to stress, morphine is quickly metabolizedto bismorphine consisting of two morphine units, followed by accumulation in the cell wall. This bismorphine binds predominantly to pectins, which possess high galacturonic acid residue contents, through ionical bonds. Our newly developed method using artificial polysaccharides demonstrated that bismorphine bridges are formed between the two amino groups of bismorphine and the carboxyl groups of galacturonic acid residues, resulting in crosslinking of galacturonic acid-containing polysaccharides to each other. The ability of bismorphine to cross-link pectins is much higher than that of Ca2+, which also acts as a cross-linker of these polysaccharides. Furthermore, weconfirmed that cross-linking of pectins through bismorphine bridges leads to resistance against hydrolysis by pectinases. These results indicated that production of bismorphine is a defense response of the opium poppy. Bismorphine formation is catalyzed by anionic peroxidase that pre-exists in the capsules and leaves of opium poppies. The constitutive presence of morphine, together with bismorphine-forming peroxidase, enables the opium poppy to rapidly induce the defense system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 18:39:34