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Titolo:
Polymorphisms for interleukin-1 beta (IL-1 beta)-511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist: Nonassociation with endometriosis
Autore:
Hsieh, YY; Chang, CC; Tsai, FJ; Wu, JY; Shi, YR; Tsai, HD; Tsai, CH;
Indirizzi:
China Med Coll Hosp, Dept Pediat & Med Genet, Taichung, Taiwan China Med Coll Hosp Taichung Taiwan ediat & Med Genet, Taichung, Taiwan
Titolo Testata:
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
fascicolo: 9, volume: 18, anno: 2001,
pagine: 506 - 511
SICI:
1058-0468(200109)18:9<506:PFIB(B>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; INFLAMMATORY-BOWEL-DISEASE; GENE POLYMORPHISMS; MESSENGER-RNA; PLASMA-LEVELS; TNF-ALPHA; PERITONEAL-MACROPHAGES; RHEUMATOID-ARTHRITIS; STROMAL CELLS; IN-VITRO;
Keywords:
endometriosis; gene polymorphism; IL-1 beta; IL-1 beta exon 5; IL-1 beta-511 promoter; IL-1receptor antagonist;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, FJ China Med Coll Hosp, Dept Pediat & Med Genet, 2 Yuh Der Rd, Taichung, Taiwan China Med Coll Hosp 2 Yuh Der Rd Taichung Taiwan ichung, Taiwan
Citazione:
Y.Y. Hsieh et al., "Polymorphisms for interleukin-1 beta (IL-1 beta)-511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist: Nonassociation with endometriosis", J AS REPROD, 18(9), 2001, pp. 506-511

Abstract

Purpose: We aimed to investigate if interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonist (IL-IRa) gene polymorphism could be used as markers of susceptibility in endometriosis. Materials and Methods: Women were divided into two groups: 1) endometriosis (n = 120); 2) nonendometriosis groups (n = 103). Polymorphisms for IL-1 beta -511 promoter, IL-1 beta exon 5, and IL-1Ra were detected by polymerasechain reaction. Genotypes and allelic frequencies for these polymorphisms in both groups were compared. Results: Proportions of different IL-1 and IL-1Ra polymorphisms in both groups were nonsignificantly different. Proportions of C homozygote/heterozygote/T homozygote for IL-1 beta -511 promoter in both groups were 1) 21.6/59.1/19.1% and 2) 26.2/50.5/23.3%. Proportions of El homozygote/heterozygote/E2 homozygote for IL-1 beta exon 5 in both groups were 1) 91.6/5/3.3% and 2) 95.15/4.85/0%. Allele I/II/IV/V for IL-1Ra in both groups were 1) 92.5/5.4/1.6/0.4% and 2) 95.1/3.9/1/0%. Conclusions. Association of endometriosis with IL-1 beta -511 promoter, IL-1 beta exon 5, and IL-1 receptor antagonist gene polymorphisms doesn't exist. These polymorphisms are not useful markers for prediction of endometriosis susceptibility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 12:28:28