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Titolo:
Feeding mode, intestinal permeability, and neopterin excretion: A longitudinal study in infants of HIV-infected south African women
Autore:
Rollins, NC; Filteau, SM; Coutsoudis, A; Tomkins, AM;
Indirizzi:
Ctr Int Child Hlth Inst Child Hlth, London WC1N 1EH, England Ctr Int ChildHlth Inst Child Hlth London England WC1N 1EH 1EH, England Univ Natal, Dept Pediat, ZA-4001 Durban, South Africa Univ Natal Durban South Africa ZA-4001 iat, ZA-4001 Durban, South Africa
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 28, anno: 2001,
pagine: 132 - 139
SICI:
1525-4135(20011001)28:2<132:FMIPAN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; TO-CHILD TRANSMISSION; BREAST-MILK;
Keywords:
HIV; exclusive breastfeeding; intestine; infant;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Filteau, SM Ctr Int Child Hlth Inst Child Hlth, 30 Guilford St, London WC1N 1EH, England Ctr Int Child Hlth Inst Child Hlth 30 Guilford St London England WC1N 1EH
Citazione:
N.C. Rollins et al., "Feeding mode, intestinal permeability, and neopterin excretion: A longitudinal study in infants of HIV-infected south African women", J ACQ IMM D, 28(2), 2001, pp. 132-139

Abstract

Exclusive breast feeding has been associated with a lower rate of mother-to-child HIV transmission than breast feeding plus other foods. To obtain further information on biologic outcomes of different feeding modes, we examined 272 infants of HIV-infected South African women at ages 1, 6, and 14 weeks. At each visit information about infant diet and morbidity was collected and infants underwent a lactulose/mannitol dual sugar intestinal permeability test. In a subset of infants, urinary neopterin excretion was measuredas an indicator of immune system activation. Infants who had themselves become HIV-infected by 14 weeks had higher (P < .01) intestinal permeability at 6 and 14 weeks and slightly (.05 < p < .1) higher neopterin excretion atall times than uninfected infants. At I week infants given no breast milk had higher (p < .05) intestinal permeability than infants given breast milkexclusively or with other foods. Intestinal permeability in infants fed breast milk plus other foods was never increased relative to that of exclusively breastfed infants. Feeding mode had no effect on neopterin excretion. Thus, infant HIV infection induces changes in gut permeability and possibly immune system activation before clinical symptoms become apparent. The effects of feeding mode on infant intestinal permeability or urinary neopterin excretion do not explain a possible protective effect of exclusive breast feeding on mother-to-child transmission of HIV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 07:45:08