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Titolo:
Antiretroviral regimen complexity, self-reported adherence, and HIV patients' understanding of their regimens: Survey of women in the HER study
Autore:
Stone, VE; Hogan, JW; Schuman, P; Rompalo, AM; Howard, AA; Korkontzelou, C; Smith, DK;
Indirizzi:
Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Gen Med Unit, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 t Med,Gen Med Unit, Boston, MA 02114 USA Brown Univ, Sch Med, Ctr Stat Sci, Providence, RI 02912 USA Brown Univ Providence RI USA 02912 Ctr Stat Sci, Providence, RI 02912 USA Wayne State Univ, Sch Med, Detroit, MI USA Wayne State Univ Detroit MI USA yne State Univ, Sch Med, Detroit, MI USA Johns Hopkins Sch Med, Baltimore, MD USA Johns Hopkins Sch Med Baltimore MD USA opkins Sch Med, Baltimore, MD USA Albert Einstein Coll Med, New York, NY USA Albert Einstein Coll Med New York NY USA tein Coll Med, New York, NY USA US Ctr Dis Control & Prevent, Atlanta, GA USA US Ctr Dis Control & Prevent Atlanta GA USA l & Prevent, Atlanta, GA USA
Titolo Testata:
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
fascicolo: 2, volume: 28, anno: 2001,
pagine: 124 - 131
SICI:
1525-4135(20011001)28:2<124:ARCSAA>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDICATION; THERAPY; INFECTION; HIV/AIDS; DISEASE;
Keywords:
adherence; antiretroviral therapy; complexity; women; HIV/AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Stone, VE Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Gen Med Unit, 50 Staniford St,9th Floor, Boston, MA 02114 USA Harvard Univ 50 Staniford St,9th Floor Boston MA USA 02114 4 USA
Citazione:
V.E. Stone et al., "Antiretroviral regimen complexity, self-reported adherence, and HIV patients' understanding of their regimens: Survey of women in the HER study", J ACQ IMM D, 28(2), 2001, pp. 124-131

Abstract

Background: Research regarding treatment adherence in chronic diseases,. such as hypertension, suggests that increasing complexity in the medication regimen is associated with decreasing patient adherence. However, less is known about the relationship between regimen complexity and adherence in thetreatment of HIV/AIDS. Objective: To examine the relationship between antiretroviral (ART) regimen complexity and patient understanding of correct regimen dosing to adherence (missing doses in the past I and 3 days). Methods: Cross-sectional survey of a cohort of women living with HIV/AIDS and enrolled in the HER (HIV Epidemiologic Research) Study. Results: Seventy-five percent of patients correctly understood the dosing frequency of their ART medications, 80% understood the food-dosing restrictions, whereas only 63% understood both. The percentage of patients with a correct understanding of dosing decreased with increasing regimen complexity(increased dosing frequency and food-dosing restrictions). Patients were more likely to have missed doses in the previous 3 days if they were taking ART medications three or more times per day or had to take one or more antiretrovirals on an empty stomach. A multivariate logistic regression model demonstrated that patients with less complex regimens (twice daily or less in frequency, no food-dosing restrictions) who correctly understood the dosing and food restrictions of their ART regimen were less likely to have skipped doses in the past three days (odds ratio [OR], 0.4; 95% confidence interval [CI], 0.2-0.7) than those with more complex regimens. Younger age and higher CD4 count were also associated with a reduced likelihood of skippingdoses. No association was found between adherence and race/ethnicity, current or past injection drug use, or education,Conclusions: Self-reported adherence is better among patients with less complex ART regimens. This is in part because patients' understanding of regimen dosing decreases as regimen complexity increases. Therefore, simplifying antiretroviral regimens may have an important role in improving patients'adherence.

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Documento generato il 20/01/20 alle ore 22:09:34