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Titolo:
Vascular response to gadolinium-containing contrast media in an ex vivo rabbit arterial model.
Autore:
Rauch, D; Bohnemann, L; Kurtz, C; Drescher, P; Kleb, B; Klose, KJ; Wagner, HJ;
Indirizzi:
Univ Freiburg, Dept Radiol, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 Radiol, D-79106 Freiburg, Germany Univ Marburg, Dept Radiol, Marburg, Germany Univ Marburg Marburg Germany niv Marburg, Dept Radiol, Marburg, Germany Med Coll Wisconsin, Dept Radiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 Radiol, Milwaukee, WI 53226 USA Univ Wisconsin Hosp & Clin, Dept Radiol, Madison, WI 53792 USA Univ Wisconsin Hosp & Clin Madison WI USA 53792 ol, Madison, WI 53792 USA
Titolo Testata:
INVESTIGATIVE RADIOLOGY
fascicolo: 10, volume: 36, anno: 2001,
pagine: 589 - 596
SICI:
0020-9996(200110)36:10<589:VRTGCM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE ANGIOGRAPHY; GADOPENTETATE DIMEGLUMINE; GADODIAMIDE INJECTION; BOLUS INJECTION; SMOOTH-MUSCLE; RAPID BOLUS; DOGS; RATS; AGENTS;
Keywords:
contrast media; vascular contractility; gadopentate; gadoteridol; ex vivo perfusion model; intravascular flow velocity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Rauch, D Univ Freiburg, Dept Radiol, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 Germany
Citazione:
D. Rauch et al., "Vascular response to gadolinium-containing contrast media in an ex vivo rabbit arterial model.", INV RADIOL, 36(10), 2001, pp. 589-596

Abstract

RATIONALE AND OBJECTIVES. To assess the influence of gadolinium-containingmagnetic resonance contrast agents on contractility of the arterial vesselwall. METHODS. Bilateral segments of rabbit carotid arteries were mounted in flow chambers, surrounded by aerated (95% O-2, 5% CO2) Krebs' solution, and perfused at a constant rate by separated and aerated Krebs' solution. Therefore, changes in pressure of the circulating Krebs' solution indicated alterations of vessel wall contractility. Viability of the artery was tested by 124 mmol/L KCI, 3 x 10(-5) mol/L phenylephrine, and 10(-5) mol/L acetylcholine. After a washout phase, gadopentate (n = 10) or gadoteridol (n = 10) wasadded to the perfusate of one carotid artery in increments of 0.1, 0.3, and 0.6 mmol/L. Concentrations up to 0.9 mmol/L and 1.2 mmol/L were tested, respectively. The contralateral artery served as a control. To assess potential relaxing effects of the media, vessels were brought into a contracted status with 3 X 10(-5) mol/L phenylephrine and then received gadolinium chelates. RESULTS. Potassium chloride and phenylephrine increased and acetylcholine decreased the pressure, indicating vasoconstriction and vasodilatation, respectively. After gadopentate and gadoteridol infusion, no statistically significant pressure changes could be detected, ruling out any vasoconstrictoror vasodilator effect. CONCLUSIONS. Gadopentetate and gadoteridol in doses of up to 1.2 mmol/L did not alter vessel wall tone. The impact of contrast media on blood pressure, as has been shown in some clinical trials, probably is not due to directchanges in arterial wall tone.

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Documento generato il 23/01/20 alle ore 04:09:12