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Titolo:
The effect of surfactants on the skin penetration of diazepam
Autore:
Shokri, J; Nokhodchi, A; Dashbolaghi, A; Hassan-Zadeh, D; Ghafourian, T; Jalali, MB;
Indirizzi:
Tabriz Med Sci Univ, Sch Pharm, Drug Appl Res Ctr, Tabriz, Iran Tabriz MedSci Univ Tabriz Iran Pharm, Drug Appl Res Ctr, Tabriz, Iran Tabriz Med Sci Univ, Sch Pharm, Div Med Chem, Tabriz, Iran Tabriz Med Sci Univ Tabriz Iran , Sch Pharm, Div Med Chem, Tabriz, Iran
Titolo Testata:
INTERNATIONAL JOURNAL OF PHARMACEUTICS
fascicolo: 1-2, volume: 228, anno: 2001,
pagine: 99 - 107
SICI:
0378-5173(20011009)228:1-2<99:TEOSOT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM LAURYL SULFATE; VITRO PERCUTANEOUS-ABSORPTION; NONIONIC SURFACTANTS; DICLOFENAC SODIUM; INVITRO; ENHANCEMENT; TRANSPORT; RAT; PERMEABILITY; PERMEATION;
Keywords:
skin absorption; enhancer; surfactants; diazepam;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Nokhodchi, A Tabriz Med Sci Univ, Sch Pharm, Drug Appl Res Ctr, Tabriz, Iran Tabriz Med Sci Univ Tabriz Iran Appl Res Ctr, Tabriz, Iran
Citazione:
J. Shokri et al., "The effect of surfactants on the skin penetration of diazepam", INT J PHARM, 228(1-2), 2001, pp. 99-107

Abstract

The percutaneous permeation of diazepam was investigated in rat skin afterapplication of a water-propylene glycol (50:50% v/v) using a diffusion cell technique. The effect of various surfactants (sodium lauryl sulfate (SLS), cetyltrimethylammonium bromide (CTAB), benzalkonium chloride or Tween 80)with different concentrations on skin permeability were evaluated. Flux, K-p, lag time and enhancement ratios (ERs) of diazepam were measured over 10h and compared with control sample (containing no surfactant). Furthermore, diazepam Solubility in presence of surfactants was determined. The in vitro permeation experiments with rat skin revealed that the surfactant enhancers varied in their ability to enhance the flux of diazepam. Benzalkonium chloride which possessed the highest lipophilicity (log P = 1.9) among cationic surfactants provided the greatest enhancement for diazepam flux (7.98-fold over control). CTAB (log P < 1) at a concentration of 1% w/w exhibited no significant increase in flux of diazepam compared to control (1.16-fold over control). The results also showed that the highest ER was obtained in presence of 1% w/w surfactant with the exception of SLS and CTAB. The increase in flux at low enhancer concentrations is normally attributed to the ability of the surfactant molecules to penetrate the skin and increase its permeability. Reduction in the rate of transport of the drug present in enhancer systems beyond 1% w/w is attributed to the ability of the surfactant toform micelles and is normally observed only if interaction between micelleand the drug occurs. The results showed that the nature of enhancer greatly influences cutaneous barrier impairment. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 00:12:20