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Titolo:
The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing hormone
Autore:
Wieczorek, I; Schulz, C; Jarry, H; Lehnert, H;
Indirizzi:
Otto Von Guericke Univ, Dept Endocrinol & Metab, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany Univ Gottingen, Dept Obstet & Gynecol, Gottingen, Germany Univ Gottingen Gottingen Germany t Obstet & Gynecol, Gottingen, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 10, volume: 25, anno: 2001,
pagine: 1566 - 1569
SICI:
0307-0565(200110)25:10<1566:TEOTSS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-COERULEUS; ANTAGONIST; ACTIVATION; RECEPTOR; BRAIN; CRF;
Keywords:
selective serotonin reuptake-inhibitors; CRH; Zucker rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Lehnert, H Otto Von Guericke Univ, Dept Endocrinol & Metab, Leipziger Str 44, D-39120Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
I. Wieczorek et al., "The effects of the selective serotonin reuptake-inhibitor fluvoxamine on body weight in Zucker rats are mediated by corticotropin-releasing hormone", INT J OBES, 25(10), 2001, pp. 1566-1569

Abstract

Brain serotonin plays a crucial role in the regulation of food intake and body weight homeostasis. Previous data suggest an interaction with corticotropin-releasing hormone (CRH). To further examine the interaction between these neurotransmitters, the selective serotonin reuptake-inhibitor (SSRI) fluvoxamine was given intraperitoneally in fa/fa Zucker rats with and without the CRH-receptor-antagonist a-helical CRH administered intracerebroventriculary (i.c.v.). The saline treated animals gained weight. Fluvoxamine led to a significant weight loss while not affecting food intake. Furthermore, insulin levels in this animal model were reduced following fluvoxamine administration. These effects were antagonized by alpha -helical CRH and are thus most likely mediated via CRH or CRH-like peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:30:06