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Titolo:
Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine
Autore:
Prow, MR; Lancashire, B; Aspley, S; Heal, DJ; Kilpatrick, IC;
Indirizzi:
Knoll Ltd, Res & Dev, Nottingham NG1 7AR, England Knoll Ltd Nottingham England NG1 7AR & Dev, Nottingham NG1 7AR, England
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 10, volume: 25, anno: 2001,
pagine: 1450 - 1453
SICI:
0307-0565(200110)25:10<1450:AEORB5>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VALVULAR ABNORMALITIES; D-FENFLURAMINE; SEROTONIN; MICRODIALYSIS; BLOOD; SIBUTRAMINE; INHIBITORS; OBESITY; HEART; 5-HYDROXYTRYPTAMINE;
Keywords:
phentermine; dexfenfluramine; in vitro; in vivo; 5HT release; anterior hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Kilpatrick, IC Knoll Ltd, Res & Dev, St Nicholas Court,25-27 Castle Gate, Nottingham NG1 7AR, England Knoll Ltd St Nicholas Court,25-27 Castle Gate Nottingham England NG1 7AR
Citazione:
M.R. Prow et al., "Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine", INT J OBES, 25(10), 2001, pp. 1450-1453

Abstract

OBJECTIVE AND DESIGN: This study examined the effects of the anti-obesity agents, phentermine and dexfenfluramine given alone or in combination, on in vitro and in vivo 5HT release from rat brain tissue. RESULTS: In vitro, phentermine was without effect on basal [H-3]5HT eff lux from hypothalamic slices whereas dexfenfluramine (10 muM) evoked a 131% increase in [H-3]5HT release. In combination, the two drugs did not alter [H-3]5HT release beyond that caused by dexfenfluramine alone. At pharmacologically equivalent doses, phentermine (5.7 mg/kg, i.p.) caused a rapid, modest elevation, and dexfenfluramine (3 mg/kg, i.p.) a larger but equally rapidelevation of extracellular 5HT in the microdialysates from the rat anterior hypothalamus. In combination, the increase in extracellular 5HT evoked bythese drugs was not significantly greater than the sum of their individualeffects. CONCLUSIONS: This study provides evidence that phentermine's actions are not restricted to catecholamine systems and indicates that combining phentermine with dexfenfluramine results in an additive increase in neuronal 5HT release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:55