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Titolo:
Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses
Autore:
Kirschning, CJ; Bauer, S;
Indirizzi:
Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany Tech Univ Munich Munich Germany D-81675 l & Hyg, D-81675 Munich, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
fascicolo: 4, volume: 291, anno: 2001,
pagine: 251 - 260
SICI:
1438-4221(200109)291:4<251:TRCSTF>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR RECEPTOR; LPS-BINDING-PROTEIN; FACTOR-KAPPA-B; GRAM-NEGATIVE BACTERIA; LEUCINE-RICH REPEAT; LIPOTEICHOIC ACID; DROSOPHILA TOLL; INNATE IMMUNITY; WALL COMPONENTS; CUTTING EDGE;
Keywords:
Toll-like receptor (TLR); nuclear factor kappa B (NF-kappa B); lipopolysaccharide (LPS); pathogen-associated molecular pattern (PAMP); pattern recognition; innate immunity;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
97
Recensione:
Indirizzi per estratti:
Indirizzo: Kirschning, CJ Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, Trogerstr 4, D-81675 Munich, Germany Tech Univ Munich Trogerstr 4 Munich Germany D-81675 ermany
Citazione:
C.J. Kirschning e S. Bauer, "Toll-like receptors: cellular signal transducers for exogenous molecular patterns causing immune responses", INT J MED M, 291(4), 2001, pp. 251-260

Abstract

Innate immunity initiates protection of the host organism against invasionand subsequent multiplication of microbes by specific recognition. Germ line-encoded receptors have been identified for microbial products such as mannan, lipopeptide, peptidoglycan (PGN), lipoteichoic acid (LTA), lipopolysaccharide (LPS), and CpG-DNA. The Drosophila Toll protein has been shown to be involved in innate immune response of the adult fruitfly. Members of thefamily of Toll-like receptors (TLRs) in vertebrates have been implicated as pattern recognition receptors (PRRs). Ten TLRs are known and six of thesehave been demonstrated to mediate cellular activation by distinct microbial products. TLR4 has been implicated as activator of adaptive immunity, andanalysis of systemic LPS responses in mice led to the identification of LPS-resistant strains instrumental in its identification as a transmembrane LPS signal transducer. Structural similarities between TLRs and receptor molecules involved in immune responses such as CD14 and the IL-1 receptors (IL-1Rs), as well as functional analysis qualified TLR2 as candidate receptor for LPS and other microbial products. Targeted disruption of the TLR9 gene in mice led to identification of TLR9 as CpG-DNA signal transducer. Involvement of TLR5 in cell activation by bacterial flagellin has been demonstrated. Further understanding of recognition and cellular signaling activated through the ancient host defense system represented by Toll will eventually lead to means for its therapeutic modulation.

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Documento generato il 29/11/20 alle ore 00:29:37