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Titolo:
Dynamic change in collateral flow associated with myocardial ischemia in humans
Autore:
Sakata, Y; Kitakaze, M; Ishikura, F; Lim, YJ; Hirayama, A; Kodama, K; Masuyama, T; Kuzuya, T; Hori, M;
Indirizzi:
Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, Suita, Osaka 565,Japan Osaka Univ Suita Osaka Japan 565 Med & Therapeut, Suita, Osaka 565,Japan Osaka Police Hosp, Div Cardiovasc, Osaka, Japan Osaka Police Hosp Osaka Japan Police Hosp, Div Cardiovasc, Osaka, Japan Kawachi Gen Hosp, Div Cardiol, Higashiosaka, Osaka, Japan Kawachi Gen Hosp Higashiosaka Osaka Japan ol, Higashiosaka, Osaka, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 2-3, volume: 80, anno: 2001,
pagine: 153 - 160
SICI:
0167-5273(200109/10)80:2-3<153:DCICFA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; CONTRAST ECHOCARDIOGRAPHY; BLOOD-FLOW; INFARCTION; PERFUSION; CIRCULATION; ANGIOPLASTY; NICORANDIL; VIABILITY; EXERCISE;
Keywords:
collateral circulation; myocardial contrast echocardiography; atrial pacing; myocardial ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sakata, Y Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut, 2-2 Yamada Oka, Suita, Osaka 565, Japan Osaka Univ 2-2 Yamada Oka Suita Osaka Japan 565 Osaka 565, Japan
Citazione:
Y. Sakata et al., "Dynamic change in collateral flow associated with myocardial ischemia in humans", INT J CARD, 80(2-3), 2001, pp. 153-160

Abstract

Background: This study sought to investigate how collateral flow changes during myocardial ischemia in patients. Methods: Myocardial contrast echocardiography (MCE) and rapid atrial pacing were performed in 20 patients with angiographically evidenced coronary collaterals from the right coronary artery (RCA) to the occluded left anterior descending coronary artery. Sonicated contrast medium was injected into the RCA before and immediately after atrial pacing to determine the peak background-subtracted contrast intensity(PI) in the collateral territory (PIA) and its ratio to PI in the control territory (PI ratio) as parameters of collateral blood flow. Lactate production in the coronary circulation during pacing was determined to assess myocardial ischemia in the collateral territory. Results: PIA showed a significant correlation with regional wall motion either before (r(squared) = -0.64, P < 0.01) or after pacing (r(squared) = -0.65, P < 0.01). Similarly, PI ratio was significantly correlated with regional wall motion either before (r(squared) = -0.54, P < 0.05) or after pacing (r(squared) = -0.64, P < 0.01). Rapid atrial pacing decreased both PIA and PI ratio significantly greater in patients with lactate production than in those without (PIA: -67 +/- 53 vs. -15 +/- 34%, P < 0.05; PI ratio: -68 +/- 49 vs. -8.2 +/- 32%, P < 0.05, respectively), while neither PIA nor PI ratio differ between the two groups of patients before pacing (PIA: 13.8 +/- 19. vs. 16.2 +/- 13.3U, P = 0.75: PI ratio: 0.70 +/- 0.71 vs. 0.87 +/- 0.65, P = 0.58, respectively). Conclusions: We concluded that (1) collateral flow determined by MCE was closely associated with regional cardiac function, and (2) not the amount of collateral flow at rest, but pacing-induced change of collateral flow seemed to be a determinant of regional ischemia in patients with coronary collaterals. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:52:50