Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Vestibular histofluorescence could be due to accumulation of both the antibiotic and its derivative, streptidine, after acute streptomycin treatment in the guinea pig
Autore:
Meza, G; Barba-Behrens, N; Granados, O; Hernandez-Cruz, A; Toxqui, A;
Indirizzi:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, MexicoCity 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Biofis, Mexico City, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico Mexico City, DF, Mexico Univ Nacl Autonoma Mexico, Fac Quim, Dept Quim Inorgan & Nucl, Mexico City04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 ty04510, DF, Mexico
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 1143 - 1148
SICI:
0213-3911(200110)16:4<1143:VHCBDT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Keywords:
histofluorescence; aminoglycosides; rodents; ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Meza, G Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Dept Neurociencias, Apdo Postal 70-253, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Apdo Postal 70-253 Mexico City DF Mexico 04510
Citazione:
G. Meza et al., "Vestibular histofluorescence could be due to accumulation of both the antibiotic and its derivative, streptidine, after acute streptomycin treatment in the guinea pig", HIST HISTOP, 16(4), 2001, pp. 1143-1148

Abstract

Acute treatment with 300 mg/kg of pigmented guinea pigs with streptomycin sulfate induces an elevation of endogenous fluorescence in vestibular ampullary cristae. Fluorescence accumulates in all compartments of the epithelium, i.e., vestibular sensory and supporting cells and nerve fibers of the stroma and it was very intense I and 12 hours after its administration. Fluorescence decreased to control levels 24 hours following streptomycin injection. Fluorescence levels were very low either in untreated animals or in animals injected with saline physiological solution: To investigate whether this fluorescence was an intrinsic property of the antibiotic or whether it was due to a derivative of it, or both, an in vitro fluorescence spectrum was performed with 100 muM solutions of streptomycin or streptidine, or both,dissolved in various buffer solutions at 488 nm of excitation. A discrete level of fluorescence was observed in the spectrum regardless of media when separate solutions of both streptomycin or streptidine were studied. Fluorescence notably increased at 522-532 nm when the solutions contained both streptomycin and streptidine together. These results suggest that streptidine putatively derived from streptomycin may contribute to the observed fluorescence accumulation in vestibular preparations after acute treatment. Thus, these metabolic properties of the inner ear which transform streptomycin into streptidine, something never considered earlier, could be claimed as partially responsible for converting atherapeutic agent into a compound which could be as harmful as STP to the inner ear.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 09:43:01