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Titolo:
Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors
Autore:
Jin, Y; Lu, HB; Liong, E; Lau, TYH; Tipoe, GL;
Indirizzi:
Univ Hong Kong, Fac Med, Dept Anat, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Fourth Mil Med Univ, Dept Oral Histol & Pathol, Stomatol Coll, Xian, Peoples R China Fourth Mil Med Univ Xian Peoples R China ol Coll, Xian, Peoples R China Univ Hong Kong, Fac Med, Dept Biochem, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Hong Kong Polytech Univ, Fac Hlth & Social Sci, Dept Optometry & Radiog, Hong Kong, Hong Kong, Peoples R China Hong Kong Polytech Univ Hong Kong Hong Kong Peoples R China ples R China
Titolo Testata:
HISTOLOGY AND HISTOPATHOLOGY
fascicolo: 4, volume: 16, anno: 2001,
pagine: 1013 - 1019
SICI:
0213-3911(200110)16:4<1013:TMOB34>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE MORPHOGENETIC PROTEIN-2; NEURONAL DIFFERENTIATION; NEURAL INDUCTION; XENOPUS; CELLS; EXPRESSION; SIGNALS; PROLIFERATION; ECTODERM; KIDNEY;
Keywords:
BMPs; nerve sheath tumor; malignant; trigeminal nerve; Schwann cell; in-situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tipoe, GL Univ Hong Kong, Fac Med, Dept Anat, Li Shu Fan Bldg,5 Sassoon Rd,5th Floor, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Li Shu FanBldg,5 Sassoon Rd,5th Floor Hong Kong Hong Kong Peoples R China
Citazione:
Y. Jin et al., "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors", HIST HISTOP, 16(4), 2001, pp. 1013-1019

Abstract

The aim of our study was to document whether relationships existed among bone morphogenetic proteins (BMPs), peripheral nerve and neoplastic lesions of nerve sheath tumors. The mRNA transcriptions of BMP-2, 3, 4 and 5 in 10 cases of schwannoma, three cases of malignant schwannoma and two cases of trigeminal neuralgia were detected using an in situ hybridization technique. Our results demonstrated that the myelin sheaths of Schwann cell from the peripheral neuroectomy of trigeminal neuralgia positively expressed mRNA ofBMP-2, 3, 4, and 5. The most interesting finding was that the nerve fibersof trigeminal nerve showed only BMP-2 positive staining. All of the neoplastic lesions of nerve sheath showed a consistent but variant expression of BMP-2, 3, 4, and 5. The expression signals of BMP-2, 3, 5 mRNA in malignantschwannoma were relatively lower than in benign lesions except for the expression of BMP-4 mRNA. Our results indicated that selected members of BMPs were expressed in the peripheral nerves that might contribute to the healthmaintenance, proliferation, regeneration and neoplastic transformation of the peripheral nerve system. Furthermore, the effects of BMP-2, 3, 4 and 5 on peripheral nervous system during neoplastic transformation might be widespread, diverse and antagonistic.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 14:01:36