Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Increased alpha(3)-fucosylation of alpha(1)-acid glycoprotein in Type I diabetic patients is related to vascular function
Autore:
Poland, DCW; Schalkwijk, CG; Stehouwer, CDA; Koeleman, CAM; van het Hof, B; van Dijk, W;
Indirizzi:
VU Med Ctr, Fac Med, Inst Immunol & Inflammatory Dis, Glycoimmunol Grp,Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands VU Med Ctr Amsterdam Netherlands NL-1081 BT 81 BT Amsterdam, Netherlands VU Med Ctr, Inst Cardiovasc Res, Dept Clin Chem, NL-1081 BT Amsterdam, Netherlands VU Med Ctr Amsterdam Netherlands NL-1081 BT 81 BT Amsterdam, Netherlands VU Med Ctr, Inst Cardiovasc Res, Dept Internal Med, NL-1081 BT Amsterdam, Netherlands VU Med Ctr Amsterdam Netherlands NL-1081 BT 81 BT Amsterdam, Netherlands
Titolo Testata:
GLYCOCONJUGATE JOURNAL
fascicolo: 3, volume: 18, anno: 2001,
pagine: 261 - 268
SICI:
0282-0080(2001)18:3<261:IAOAGI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIALYL-LEWIS-X; ALPHA-1-ACID GLYCOPROTEIN; RHEUMATOID-ARTHRITIS; ACCEPTOR SPECIFICITY; CONCANAVALIN-A; GLYCOSYLATION; EXPRESSION; ALPHA-3-FUCOSYLATION; INTERLEUKIN-6; INFLAMMATION;
Keywords:
Type I diabetic; alpha(1)-acid glycoprotein; alpha(3)-fucosylation; (s)Le(x); albuminuria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: van Dijk, W VU Med Ctr, Fac Med, Inst Immunol & Inflammatory Dis, Glycoimmunol Grp,Dept Mol Cell Biol, Van der Boechorststr 7, NL-1081 BT Amsterdam, Netherlands VU Med Ctr Van der Boechorststr 7 Amsterdam Netherlands NL-1081 BT
Citazione:
D.C.W. Poland et al., "Increased alpha(3)-fucosylation of alpha(1)-acid glycoprotein in Type I diabetic patients is related to vascular function", GLYCOCON J, 18(3), 2001, pp. 261-268

Abstract

Diabetic mellitus is attended by the development of endothelial dysfunction which is suggested to be accompanied with a chronic low-degree of inflammation. During a chronic hepatic inflammatory response, specific changes in glycosylation of the acute phase protein alpha (1)-acid glycoprotein (AGP) can be detected. In this report we studied the changes in glycosylation of AGP in more detail and evaluated the relation between a change in glycosylation of AGP and urinary albumin secretion in Type I diabetic patients. The glycosylation of AGP, studied by crossed affinity immunoelectrophoresis (CAIE) and high pH anion exchange chromatography with pulse amperometric detection (HPAEC-PAD), showed an increase in alpha3-fucosylation. Staining with an antibody against sialyl Lewis(x) (sLe(x)) implied that part of the alpha3-fucosylation was present in a sLe(x)-conformation. In the group of Type Idiabetic patients with increased urinary albumin excretion, a significant increase in alpha3-fucosylation of AGP (p<0.0005) could be detected. Therefore, the increased <alpha>3-fucosylation of AGP can be used as an additional marker for the development of vascular complications in Type I diabetic patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:49:30