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Titolo:
A simple and rapid method for calculating identity-by-descent matrices using multiple markers
Autore:
Pong-Wong, R; George, AW; Woolliams, JA; Haley, CS;
Indirizzi:
Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland Roslin Inst Roslin Midlothian Scotland EH25 9PS 9PS, Midlothian, Scotland
Titolo Testata:
GENETICS SELECTION EVOLUTION
fascicolo: 5, volume: 33, anno: 2001,
pagine: 453 - 471
SICI:
0999-193X(200109/10)33:5<453:ASARMF>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE TRAIT LOCI; LINKAGE; PREDICTION; PEDIGREES; VALUES;
Keywords:
IBD; QTL mapping; genetic relationships; marker assisted selection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Pong-Wong, R Roslin Inst, Roslin EH25 9PS, Midlothian, Scotland Roslin Inst Roslin Midlothian Scotland EH25 9PS an, Scotland
Citazione:
R. Pong-Wong et al., "A simple and rapid method for calculating identity-by-descent matrices using multiple markers", GEN SEL EVO, 33(5), 2001, pp. 453-471

Abstract

A fast, partly recursive deterministic method for calculating Identity-by-Descent (IBD) probabilities was developed with the objective of using IBD in Quantitative Trait Locus (QTL) mapping. The method combined a recursive method for a single marker locus with a method to estimate IBD between sibs using multiple markers. Simulated data was used to compare the deterministic method developed in the present paper with a stochastic method (LOKI) forprecision in estimating IBD probabilities and performance in the task of QTL detection with the variance component approach. This comparison was madein a variety of situations by varying family size and degree of polymorphism among marker loci. The following were observed for the deterministic method relative to MCMC: (i) it was an order of magnitude faster; (ii) its estimates of IBD probabilities were found to agree closely, even though it does not extract information when haplotypes are not known with certainty; (iii) the shape of the profile for the QTL test statistic as a function of location was similar, although the magnitude of the test statistic was slightly smaller; and (iv) the estimates of QTL variance was similar. It was concluded that the method proposed provided a rapid means of calculating the IBDmatrix with only a small loss in precision, making it an attractive alternative to the use of stochastic MCMC methods. Furthermore, developments in marker technology providing denser maps would enhance the relative advantageof this method.

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Documento generato il 03/04/20 alle ore 02:48:25