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Titolo:
Distribution of lod scores in oligogenic linkage analysis
Autore:
Williams, JT; North, KE; Martin, LJ; Comuzzie, AG; Goring, HHH; Blangero, J;
Indirizzi:
SW Fdn Biomed Res, Dept Genet, San Antonio, TX 78245 USA SW Fdn Biomed Res San Antonio TX USA 78245 net, San Antonio, TX 78245 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S805 - S810
SICI:
0741-0395(2001)21:<S805:DOLSIO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUISANCE PARAMETER; PEDIGREES; IDENTITY; DESCENT; TRAITS;
Keywords:
boundary; empirical lod score; likelihood ratio test; linkage analysis; oligogenic model; statistical genetics;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, JT SW Fdn Biomed Res, Dept Genet, POB 760549, San Antonio, TX 78245 USA SW Fdn Biomed Res POB 760549 San Antonio TX USA 78245 245 USA
Citazione:
J.T. Williams et al., "Distribution of lod scores in oligogenic linkage analysis", GENET EPID, 21, 2001, pp. S805-S810

Abstract

In variance component oligogenic linkage analysis it can happen that the residual additive genetic variance bounds to zero when estimating the effectof the i(th) quantitative trait locus. Using quantitative trait Q I from the Genetic Analysis Workshop 12 simulated general population data, we compare the observed lod scores from oligogenic linkage analysis with the empirical lod score distribution under a null model of no linkage. We find that zero residual additive genetic variance in the null model alters the usual distribution of the likelihood-ratio statistic. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 13:46:22