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Titolo:
Quantitative trait linkage analysis of the liability underlying a common oligogenic disease
Autore:
Maher, BS; Vanyukov, MM; Cooper, ME; Neiwswanger, K; Marazita, ML;
Indirizzi:
Univ Pittsburgh, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 tsburgh, Pittsburgh, PA 15261 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S720 - S725
SICI:
0741-0395(2001)21:<S720:QTLAOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Keywords:
liability; pedigree discriminant analysis; quantitative trait;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
4
Recensione:
Indirizzi per estratti:
Indirizzo: Maher, BS Univ Pittsburgh, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ittsburgh, PA 15261 USA
Citazione:
B.S. Maher et al., "Quantitative trait linkage analysis of the liability underlying a common oligogenic disease", GENET EPID, 21, 2001, pp. S720-S725

Abstract

We utilized pedigree discriminant and factor analytic approaches to combine multivariate phenotypic information into a single liability phenotype in the isolate and general populations. We applied two-stage relative-pair quantitative trait linkage analysis to detect genetic contributions to variation in the resulting liability phenotypes. Linkage analysis revealed severalregions of suggestive linkage in both the general and isolate populations,the majority of which appear in retrospect to be false positives. A likelyexplanation is an overall lack of power given that we tested hypotheses indata from only one replicate. However, it may be possible that a constructthat ignores affection status when using liability-associated characteristics as indicators of this construct is not the most effective approach in modeling the liability underlying a complex phenotype. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/21 alle ore 00:17:35