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Titolo:
Exploiting linkage disequilibrium in population isolates
Autore:
Culverhouse, R; Lin, J; Liu, KY; Suarez, BK;
Indirizzi:
Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA WashingtonUniv St Louis MO USA 63110 pt Psychiat, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Genet, St Louis, MO 63110 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S429 - S434
SICI:
0741-0395(2001)21:<S429:ELDIPI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Keywords:
case/control; haplotypes; linkage disequilibrium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Culverhouse, R Washington Univ, Sch Med, Dept Psychiat, Box 8134,660 S Euclid, St Louis, MO 63110 USA Washington Univ Box 8134,660 S Euclid St Louis MO USA 63110
Citazione:
R. Culverhouse et al., "Exploiting linkage disequilibrium in population isolates", GENET EPID, 21, 2001, pp. S429-S434

Abstract

A comparison of haplotype frequencies between unrelated cases and controlsfrom population isolates identifies a strong signal for the presence/absence of the discrete phenotype in an interval on chromosome 6 bounded by markers 34 and 35. We define a dissimilarity index, D, which is sensitive to differences in allele distributions and differences in the patterns of linkage disequilibrium between cases and controls. We describe two statistical methods to utilize D: a method appropriate for a single moderately sized sample and a sequential approach appropriate for multiple small independent samples. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 12:12:09