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Titolo:
Genome-wide approaches for identifying interacting susceptibility regions for asthma
Autore:
Colilla, S; Tsalenko, A; Pluznikov, A; Cox, NJ;
Indirizzi:
Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Dept Human Genet, Chicago, IL 60637 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S266 - S271
SICI:
0741-0395(2001)21:<S266:GAFIIS>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Keywords:
conditional analysis; correlation; cluster analysis; epistasis; interaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
6
Recensione:
Indirizzi per estratti:
Indirizzo: Colilla, S Univ Chicago, Dept Human Genet, 920 E 58th St, Chicago, IL 60637 USA Univ Chicago 920 E 58th St Chicago IL USA 60637 o, IL 60637 USA
Citazione:
S. Colilla et al., "Genome-wide approaches for identifying interacting susceptibility regions for asthma", GENET EPID, 21, 2001, pp. S266-S271

Abstract

A genome-wide correlation analysis and cluster analysis were utilized to determine chromosomal regions that had similar nonparametric linkage scores across families in order to locate interacting susceptibility loci for asthma. Conditional analysis was performed to detect any increase in lod score over baseline. Eight of the strongest 5% of the correlations in the German and CSGA asthma data sets occurred in both data sets. The strongest positive correlations found in both data sets were between the 200 cM region on chromosome 2 with chromosome 12 at 90-120 cM (r = 0.26) and also with chromosome 6 at 40-70 cM (r = 0.24). While the cluster analysis did not find any regions that clustered across data sets, this method did detect clustering in regions that have been previously linked to asthma. ((C)) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:13:14