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Titolo:
A pedigree partitioning approach to quantitative trait loci mapping of IgEserum level in the GAW12 Hutterite data
Autore:
Pankratz, VS; Iturria, SJ;
Indirizzi:
Mayo Clin & Mayo Fdn, Biostat Sect, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 Sect, Rochester, MN 55905 USA
Titolo Testata:
GENETIC EPIDEMIOLOGY
, volume: 21, anno: 2001, supplemento:, 1
pagine: S258 - S263
SICI:
0741-0395(2001)21:<S258:APPATQ>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENOME-WIDE SEARCH; LINKAGE; ASTHMA;
Keywords:
cluster analysis; factor analysis; quantitative trait linkage analysis; variance components;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Pankratz, VS Mayo Clin & Mayo Fdn, Biostat Sect, 200 1st St SW, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn 200 1st St SW Rochester MN USA 55905 USA
Citazione:
V.S. Pankratz e S.J. Iturria, "A pedigree partitioning approach to quantitative trait loci mapping of IgEserum level in the GAW12 Hutterite data", GENET EPID, 21, 2001, pp. S258-S263

Abstract

We present a semi-automatic method that uses principles from factor analysis to subdivide large pedigrees into smaller, non-overlapping sub-pedigrees. Application of our method to the Genetic Analysis Workshop 12 Hutterite pedigree yielded 12 sub-pedigrees that were used to carry out a genome-wide linkage scan for IgE serum level in SOLAR. Two-point analyses resulted in strong evidence for linkage to two marker loci on chromosome 1, D1S3723 (lod= 3.70) and D1S534 (lod = 3.58). Multipoint analysis resulted in a maximumlod of 4.58 on chromosome 1 at 143 cM. After extending the two pedigrees that contributed the most evidence for linkage, the maximum lod score decreased to 4.18, with most of the evidence for linkage due to a single large sub-pedigree. ((C)) 2001 Wiley-Liss, Inc.

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Documento generato il 26/01/20 alle ore 10:23:56